{"id":"W3203237663","doi":"10.1007/978-1-0716-1740-3_17","title":"Generation of Protein Inhibitors for Validation of Cancer Drug Targets Identified in Functional Genomic Screens","year":2021,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Computational biology; Small molecule; Drug development; Drug; Phage display; Drug discovery; Target protein; Biology; Protein–protein interaction; Gene; Bioinformatics; Biochemistry; Genetics; Pharmacology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009050976,0.001091197,0.001044627,0.000883481,0.000365505,0.0006307614,0.0007121809,0.0006118495,0.00213191],"category_scores_gemma":[0.0007569607,0.0004455778,0.0006361224,0.0006842085,0.0003235315,0.0002604786,0.0003884705,0.001246737,0.0009329568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006603156,"about_ca_system_score_gemma":0.0004868711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008457982,"about_ca_topic_score_gemma":0.001740343,"domain_scores_codex":[0.9994697,0.0001094397,0.00004720331,0.00007271157,0.0002189199,0.00008210434],"domain_scores_gemma":[0.9996732,0.0001023124,0.0000631974,0.00004861111,0.0000780546,0.00003464663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001537634,0.00009751169,0.0002591958,0.0000944141,0.00003656838,0.00006376849,0.00001246829,0.0006294991,0.994306,0.0003163624,0.0002343087,0.003796074],"study_design_scores_gemma":[0.0000877307,0.0004418062,0.0008166637,0.00001074536,0.000107008,0.0002010789,0.000009250213,0.002132683,0.9907706,0.00009090779,0.005322993,0.000008536012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8242148,0.007126055,0.1475429,0.0009009265,0.0002714517,0.001431982,0.008071445,0.001364762,0.009075575],"genre_scores_gemma":[0.9108142,0.005854749,0.06328651,0.000443499,0.00005772792,0.0008593494,0.01178016,0.000258961,0.006644731],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.00213191,"threshold_uncertainty_score":0.007131934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09213803014148113,"score_gpt":0.4533983029906909,"score_spread":0.3612602728492098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}