{"id":"W3203240907","doi":"10.1101/2021.09.22.461414","title":"Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; McGill University","keywords":"Gluconeogenesis; Internal medicine; Endocrinology; Alanine; Alanine transaminase; Aspartate transaminase; Hepatocyte; Amino acid; Chemistry; Gene knockdown; Biochemistry; Biology; Medicine; Metabolism; Apoptosis; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002113243,0.0004350079,0.0003585615,0.0002884015,0.0001540207,0.000393512,0.0002386655,0.0002494505,0.002009516],"category_scores_gemma":[0.00008142307,0.0001851929,0.0002752169,0.0002126026,0.0003427225,0.0001642362,0.0002247519,0.0006707643,0.0006246608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002608852,"about_ca_system_score_gemma":0.0002717087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005810424,"about_ca_topic_score_gemma":0.0009278919,"domain_scores_codex":[0.9998987,0.00001432222,0.00001402803,0.00002457541,0.00002707496,0.00002132715],"domain_scores_gemma":[0.9999287,0.000008170739,0.00001977406,0.00001034461,0.00000822862,0.00002479194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000241395,0.00002320416,0.0001128898,0.00004745016,0.000007502144,0.00002485536,0.000009346342,0.00005815489,0.9980801,0.0001513547,0.000181612,0.001062019],"study_design_scores_gemma":[0.0000523372,0.0001301762,0.001543817,0.000006020933,0.00002081887,0.00008530058,0.00002033948,0.0005757051,0.9930067,0.00007355776,0.004480888,0.000004262874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798568,0.003774329,0.00843625,0.000860243,0.0003396684,0.00004893462,0.002092067,0.0005758915,0.004015868],"genre_scores_gemma":[0.9742379,0.002904887,0.007585949,0.0003308107,0.0000712743,0.00008614574,0.002644809,0.0002177654,0.01192045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002009516,"threshold_uncertainty_score":0.00672251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007957581300246932,"score_gpt":0.1975483955057185,"score_spread":0.1895908142054715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}