{"id":"W3203254808","doi":"10.1016/j.jaci.2021.09.028","title":"ORMDL3 regulates cigarette smoke–induced endoplasmic reticulum stress in airway smooth muscle cells","year":2021,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Sanming Project of Medicine in Shenzhen; Imperial College London; University of Manitoba","keywords":"Unfolded protein response; Endoplasmic reticulum; Small interfering RNA; Gene knockdown; COPD; Downregulation and upregulation; Biology; Protein kinase A; Endocrinology; Internal medicine; Inflammation; Cell biology; Cancer research; Kinase; Immunology; Apoptosis; Medicine; Biochemistry; Transfection","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001758391,0.0002659723,0.0002844911,0.0002973101,0.0003940129,0.0005294716,0.0002566369,0.0004054515,0.001676084],"category_scores_gemma":[0.0001384776,0.0001991068,0.0004749412,0.0002532694,0.0002813897,0.0002469584,0.0003622269,0.0007713495,0.0004204882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006558169,"about_ca_system_score_gemma":0.0003446328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002111385,"about_ca_topic_score_gemma":0.003329555,"domain_scores_codex":[0.9997389,0.00003601267,0.00002093521,0.00003912047,0.00005870349,0.0001062247],"domain_scores_gemma":[0.9999105,0.00000896221,0.0000272447,0.00001082448,0.00001632675,0.00002614247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005481651,0.00006350755,0.00133095,0.00004155698,0.00001496552,0.0001188109,0.00002776641,0.00005437691,0.9967577,0.0001157348,0.0001476072,0.0007788695],"study_design_scores_gemma":[0.0001548268,0.0004603594,0.1389257,0.00002119789,0.0001110354,0.0003844731,0.0005111118,0.003238765,0.8505236,0.0002031053,0.005441855,0.00002397113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959509,0.001337743,0.000741985,0.0003614467,0.00008534829,0.00001641515,0.0005429714,0.00007239023,0.0008907349],"genre_scores_gemma":[0.9963267,0.0004914349,0.000361886,0.0001394276,0.00001232331,0.00002864264,0.0006647187,0.00001232041,0.001962434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002111385,"threshold_uncertainty_score":0.005607069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370201069802554,"score_gpt":0.2764254625686904,"score_spread":0.2627234518706649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}