{"id":"W3203265145","doi":"10.1007/s40262-021-01072-4","title":"Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling","year":2021,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Child Health and Human Development; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of North Carolina at Chapel Hill; Duke Clinical Research Institute; National Institute of General Medical Sciences; Penn State College of Medicine; Wichita Medical Research and Education Foundation; Texas Christian University; American Foundation for Pharmaceutical Education; Pennsylvania State University; University of Louisville; Health Science Center, University of North Texas; University of Pennsylvania; Children's Hospital of Philadelphia","keywords":"Pharmacokinetics; Population; Dosing; Clindamycin; Medicine; Obesity; Volume of distribution; Trimethoprim; Pharmacology; Sulfamethoxazole; Internal medicine; Antibiotics; Chemistry; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00378446,0.0005695473,0.0005464536,0.0006014666,0.0004182244,0.0008169058,0.001276308,0.0006307461,0.00187889],"category_scores_gemma":[0.01011557,0.0003845561,0.001006025,0.0003486448,0.0004195165,0.000675667,0.001177992,0.0008883702,0.0002989529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00117817,"about_ca_system_score_gemma":0.002353044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008547821,"about_ca_topic_score_gemma":0.005920179,"domain_scores_codex":[0.9988469,0.0006875073,0.00006413772,0.0001581802,0.000173283,0.00007001581],"domain_scores_gemma":[0.99566,0.00258925,0.0004465249,0.0003132318,0.0007607937,0.0002301785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001022293,0.00117426,0.09305456,0.0001753526,0.0002813258,0.000433139,0.0004501073,0.8235837,0.004383227,0.00586297,0.002651571,0.06692763],"study_design_scores_gemma":[0.0002083669,0.001016688,0.009584495,0.00003813456,0.00007358386,0.0001880595,0.0002048508,0.9813602,0.002389099,0.001808524,0.003093917,0.00003419993],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7457374,0.0001374985,0.2455842,0.0004951356,0.00007885303,0.00128546,0.001725606,0.0007100172,0.004245816],"genre_scores_gemma":[0.8383049,0.0001543064,0.1571175,0.0001578017,0.00002160629,0.001430876,0.002033974,0.00005629443,0.0007227953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008547821,"threshold_uncertainty_score":0.02001441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1247944405612429,"score_gpt":0.4197282748783461,"score_spread":0.2949338343171031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}