{"id":"W3203265145","doi":"10.1007/s40262-021-01072-4","title":"Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling","year":2021,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Child Health and Human Development; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of North Carolina at Chapel Hill; Duke Clinical Research Institute; National Institute of General Medical Sciences; Penn State College of Medicine; Wichita Medical Research and Education Foundation; Texas Christian University; American Foundation for Pharmaceutical Education; Pennsylvania State University; University of Louisville; Health Science Center, University of North Texas; University of Pennsylvania; Children's Hospital of Philadelphia","keywords":"Pharmacokinetics; Population; Dosing; Clindamycin; Medicine; Obesity; Volume of distribution; Trimethoprim; Pharmacology; Sulfamethoxazole; Internal medicine; Antibiotics; Chemistry; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001104842,0.0002090836,0.0005988957,0.00007502046,0.00005257167,0.000007715967,0.00008960047,0.0001153792,0.00007294703],"category_scores_gemma":[0.000326113,0.0001726745,0.0001445907,0.0002144642,0.0001414865,0.00003128476,0.0000674857,0.0002130657,8.405558e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002686356,"about_ca_system_score_gemma":0.000329925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002847603,"about_ca_topic_score_gemma":9.875952e-7,"domain_scores_codex":[0.9976241,0.0001498731,0.001004618,0.000431927,0.0005699867,0.0002195249],"domain_scores_gemma":[0.9978303,0.0002380575,0.0003211965,0.00021705,0.001207339,0.0001860659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.005711752,0.00854577,0.2941117,0.001169587,0.001912365,0.0000136061,0.0002399189,0.1843713,0.2262024,0.0003766234,0.0003214335,0.2770236],"study_design_scores_gemma":[0.01157478,0.0006215444,0.2586595,0.0001605314,0.001755759,0.000008182441,0.00001686414,0.6617396,0.06512436,0.00005309357,0.00008816839,0.0001976627],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870032,0.000296464,0.01138677,0.0001307645,0.0001113094,0.0009510925,0.00002686625,0.00002237317,0.0000711404],"genre_scores_gemma":[0.9692206,0.0001698035,0.02983506,0.0003071066,0.0001550502,0.00001209015,0.0002564968,0.00002916255,0.00001465893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4773683,"threshold_uncertainty_score":0.704146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1247944405612429,"score_gpt":0.4197282748783461,"score_spread":0.2949338343171031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}