{"id":"W3203327049","doi":"10.3389/fpsyt.2021.722378","title":"Heterogeneity in Fragile X Syndrome Highlights the Need for Precision Medicine-Based Treatments","year":2021,"lang":"en","type":"review","venue":"Frontiers in Psychiatry","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Fragile X syndrome; Precision medicine; Drug trial; Intellectual disability; Clinical trial; Medicine; Autism; Drug development; Fragile x; Genetic heterogeneity; Drug; Efficacy; Bioinformatics; Phenotype; Psychiatry; Pathology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002056455,0.0004467175,0.0009364634,0.0002009248,0.00007779947,0.00001872872,0.0004725396,0.0004204031,0.000008392188],"category_scores_gemma":[0.00003616211,0.0003097015,0.0003665362,0.0003298498,0.00007959018,0.000002063166,0.00008919665,0.0001818813,0.000002140812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006427251,"about_ca_system_score_gemma":0.0003905828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001107428,"about_ca_topic_score_gemma":0.0001019571,"domain_scores_codex":[0.997909,0.0002006879,0.0006161419,0.0007428662,0.0001743827,0.000356922],"domain_scores_gemma":[0.9990716,0.00002565269,0.0002020196,0.0006061912,0.00002619143,0.00006832763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002249396,0.001395554,0.006823771,0.007660021,0.00115323,0.00004939539,0.0001030836,0.0001892015,0.00009080753,0.00006523862,0.3714854,0.6107593],"study_design_scores_gemma":[0.001519969,0.0003157075,0.001051107,0.002942784,0.0002036066,0.0000135891,0.00005697483,0.00002132562,0.00002728712,0.0001414553,0.9932972,0.0004090587],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003320022,0.9876831,0.0007002757,0.0003104826,0.006436846,0.00138814,0.00007367775,0.000005966594,0.00008144561],"genre_scores_gemma":[0.0005242637,0.9924425,0.004700789,0.0002848535,0.00007008841,0.0005247652,0.001178445,0.0000737408,0.0002005346],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6218117,"threshold_uncertainty_score":0.9999355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0194580886920961,"score_gpt":0.3026501678911834,"score_spread":0.2831920791990873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}