{"id":"W3203350051","doi":"10.1021/acschembio.1c00273","title":"Engineering the Sialome","year":2021,"lang":"en","type":"review","venue":"ACS Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Glycocalyx; Glycan; Sialic acid; Glycobiology; Biochemistry; Chemistry; Monosaccharide; Cell biology; Biology; Glycoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003589374,0.0007838529,0.0005705185,0.0008484752,0.0002334566,0.001046706,0.0005629106,0.00082258,0.001777249],"category_scores_gemma":[0.0003087055,0.000288368,0.0004633357,0.0007617101,0.0003878688,0.001419113,0.0009589677,0.001563644,0.001777709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005806991,"about_ca_system_score_gemma":0.0005573605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006842656,"about_ca_topic_score_gemma":0.0008956195,"domain_scores_codex":[0.9998635,0.00001890726,0.00001055276,0.0000260246,0.00005279588,0.00002814999],"domain_scores_gemma":[0.9999413,0.00001817867,0.00001057951,0.00000527533,0.00001572404,0.000008861198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001398375,0.0001219627,0.000398503,0.0151244,0.000119542,0.0005783003,0.0001721377,0.001445689,0.1232066,0.06461354,0.01729221,0.7767873],"study_design_scores_gemma":[0.000009149629,0.00009590708,0.0002529313,0.0006743725,0.00005577957,0.0007275753,0.00004510581,0.0003396436,0.04160588,0.00399937,0.9521731,0.00002124637],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005937345,0.9714388,0.006777034,0.0008365372,0.0008797098,0.00003714372,0.0001809516,0.0001048104,0.01380769],"genre_scores_gemma":[0.02061986,0.9676681,0.003766428,0.0005407381,0.0001374237,0.00004023919,0.0002992278,0.00002751485,0.006900507],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001777249,"threshold_uncertainty_score":0.005945504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03158707095366452,"score_gpt":0.3413570114621495,"score_spread":0.3097699405084849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}