{"id":"W3203350051","doi":"10.1021/acschembio.1c00273","title":"Engineering the Sialome","year":2021,"lang":"en","type":"review","venue":"ACS Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Glycocalyx; Glycan; Sialic acid; Glycobiology; Biochemistry; Chemistry; Monosaccharide; Cell biology; Biology; Glycoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001932463,0.0002671094,0.0006052356,0.00004034472,0.00004189111,0.00002493064,0.0005223899,0.0007099402,0.0001099238],"category_scores_gemma":[0.000603956,0.0001700609,0.0003362907,0.0001895124,0.0001075643,8.35473e-7,0.0004459017,0.0004248802,0.0001198209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002493517,"about_ca_system_score_gemma":0.0001988199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004255259,"about_ca_topic_score_gemma":8.239852e-7,"domain_scores_codex":[0.998652,0.0001293604,0.0003063893,0.000479221,0.00008415207,0.0003488381],"domain_scores_gemma":[0.9990827,0.00009115964,0.00008075709,0.0005974995,0.00006578422,0.00008210084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005615692,0.00003553364,0.000001579746,0.0009764853,0.0002708717,0.000009396715,0.000004100299,6.230292e-7,0.05868689,0.0008492609,0.004903429,0.9342562],"study_design_scores_gemma":[0.00007976799,0.00002581358,1.07328e-7,0.0002110177,0.00004547303,0.00006222278,0.00000135565,0.000001396258,0.00751193,0.00000933428,0.9918573,0.0001943145],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001396878,0.9987425,0.00007246056,0.00008686455,0.0001420706,0.0002926826,0.00003530653,0.00001397411,0.0004745065],"genre_scores_gemma":[0.0001966456,0.9965129,0.0001162575,0.0001038503,0.0006415105,0.0001436588,0.001641895,0.00003696114,0.0006063269],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9869539,"threshold_uncertainty_score":0.693488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03158707095366452,"score_gpt":0.3413570114621495,"score_spread":0.3097699405084849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}