{"id":"W3203367348","doi":"10.1073/pnas.2012591118","title":"A shared mechanistic pathway for pyridoxal phosphate–dependent arginine oxidases","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Microbial metabolism and enzyme function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"Generalitat de Catalunya; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Ministerio de Ciencia e Innovación; Government of Canada","keywords":"Arginine; Biochemistry; Pyridoxal phosphate; Chemistry; Pyridoxal 5-Phosphate; Pyridoxal; Phosphate; Enzyme; Cofactor; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004562037,0.00006887216,0.0000979264,0.00003282322,0.000111181,0.00001435001,0.000278894,0.00007019789,0.00001946365],"category_scores_gemma":[0.0006894161,0.00005032265,0.00007597831,0.0001914235,0.0001397417,0.00001527039,0.0001079725,0.0000431002,6.127518e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006053533,"about_ca_system_score_gemma":0.00005461797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001667227,"about_ca_topic_score_gemma":1.360335e-7,"domain_scores_codex":[0.9991601,0.000003597466,0.0001825991,0.0002280059,0.000318616,0.0001071194],"domain_scores_gemma":[0.9994322,0.00001809405,0.0001790903,0.000008348772,0.0003391905,0.00002304931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003160202,0.00003287558,0.00008623303,0.00003916697,0.00001193656,3.557904e-9,0.00001204874,0.00003062391,0.9822274,0.01488348,0.002472076,0.0001725641],"study_design_scores_gemma":[0.000235758,0.00005324444,0.00131662,0.00002574931,0.00001157876,0.000007592734,0.00005768977,0.00009520553,0.9857568,0.008321222,0.004058452,0.00006009553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996362,0.0009189779,0.00008018938,0.001083822,0.0001056412,0.0002040529,0.0002692321,0.000005670476,0.0009704111],"genre_scores_gemma":[0.9970452,0.00004673861,0.001813018,0.000324448,0.0001778954,0.00001669955,0.000003717862,0.000004009715,0.0005683355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006562258,"threshold_uncertainty_score":0.2052098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02874970115311706,"score_gpt":0.2737580247063301,"score_spread":0.2450083235532131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}