{"id":"W3203376084","doi":"10.1016/j.immuni.2021.09.005","title":"Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity","year":2021,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; National Institute of General Medical Sciences; Merck","keywords":"Biology; Lineage (genetic); Immunity; Monocyte; Bruton's tyrosine kinase; PI3K/AKT/mTOR pathway; Immunology; Cancer research; Cell biology; Cell lineage; Cellular differentiation; Immune system; Genetics; Signal transduction; Gene; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002477743,0.0001627279,0.0003114635,0.00007523909,0.0002831781,0.00001739151,0.0001428419,0.0001466917,0.000639149],"category_scores_gemma":[0.0001467873,0.0001324102,0.0001379419,0.0001958717,0.0002607369,0.0001861861,0.0001859337,0.0004548824,0.00003060187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003141862,"about_ca_system_score_gemma":0.00006598646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004173064,"about_ca_topic_score_gemma":0.00004684996,"domain_scores_codex":[0.9983794,0.000741518,0.0004763298,0.0001711952,0.00005399613,0.0001775516],"domain_scores_gemma":[0.9986612,0.0002105334,0.0003793347,0.0004570761,0.0002794023,0.00001244422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007341592,0.0004721741,0.001399959,0.0001437092,0.00006238764,5.912603e-7,0.0007523223,0.000002309115,0.9965107,0.00004100441,0.0001475671,0.0003938052],"study_design_scores_gemma":[0.000724839,0.0001344032,0.0463306,0.0001162788,0.00006851576,0.00001941877,0.0013651,0.00002138702,0.9504488,0.00003755384,0.0006177984,0.0001153163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950787,0.001934699,0.0001881965,0.00004029679,0.001823566,0.0002094656,0.00002727707,0.00002461013,0.0006731708],"genre_scores_gemma":[0.9977371,0.0002611383,0.00003543829,0.0000417055,0.00001395635,0.000009434735,0.0001359259,0.00001203315,0.001753315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04606196,"threshold_uncertainty_score":0.6998234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141182157262697,"score_gpt":0.2231145442482935,"score_spread":0.2117027226756665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}