{"id":"W3203462303","doi":"10.1038/s41434-021-00295-1","title":"Long-term safety and efficacy of intramyocardial adenovirus-mediated VEGF-DΔNΔC gene therapy eight-year follow-up of phase I KAT301 study","year":2021,"lang":"en","type":"article","venue":"Gene Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Kuopion Yliopistollinen Sairaala","keywords":"Mace; Medicine; Hazard ratio; Internal medicine; Adverse effect; Genetic enhancement; Angina; Confidence interval; Incidence (geometry); Randomized controlled trial; Surgery; Myocardial infarction; Percutaneous coronary intervention; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001591674,0.000414565,0.001047154,0.0001363111,0.0002008185,0.0003989626,0.0003045201,0.0005323295,0.0006319562],"category_scores_gemma":[0.0006844345,0.0001315932,0.0006320809,0.0001283293,0.0003602161,0.0003118906,0.000146812,0.0008893306,0.0001838885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003043584,"about_ca_system_score_gemma":0.0003397287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002206333,"about_ca_topic_score_gemma":0.000323625,"domain_scores_codex":[0.9996605,0.0001411893,0.0000285672,0.0000522514,0.00005179832,0.00006565962],"domain_scores_gemma":[0.9993166,0.0001414655,0.0002052325,0.0000943526,0.00006790094,0.0001744387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3753217,0.03895364,0.07183456,0.0008631647,0.002096205,0.0008172686,0.0003188798,0.002795276,0.2978533,0.0002453356,0.002142264,0.2067584],"study_design_scores_gemma":[0.05404226,0.7646571,0.147489,0.00004549953,0.0009003646,0.0007974271,0.00007896358,0.001947015,0.02745222,0.0001643612,0.00238476,0.0000410131],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980108,0.0009485975,0.0003540749,0.00004612068,0.00001657426,0.0001038608,0.0001860458,0.00002094707,0.00031306],"genre_scores_gemma":[0.9983664,0.0003867027,0.0002238407,0.0001326205,0.00002663746,0.0001086726,0.0004341278,0.000004835947,0.0003162488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001591674,"threshold_uncertainty_score":0.008417666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03771391769886721,"score_gpt":0.3372389796019408,"score_spread":0.2995250619030735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}