{"id":"W3203481388","doi":"10.3390/molecules26196008","title":"Concise Large-Scale Synthesis of Tomatidine, A Potent Antibiotic Natural Product","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Natural product; Diosgenin; Combinatorial chemistry; Total synthesis; Chemistry; Prodrug; Stereochemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001500075,0.0001645951,0.0004231405,0.00007001877,0.000052179,0.00001590857,0.00008813902,0.00006258555,0.0001492321],"category_scores_gemma":[0.000823361,0.0001208143,0.0001687318,0.0002971976,0.00006813236,0.00004267552,0.0000775935,0.0001431271,0.00002739659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003025269,"about_ca_system_score_gemma":0.00009987078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001314789,"about_ca_topic_score_gemma":0.0000154403,"domain_scores_codex":[0.9987745,0.00006024416,0.0002879484,0.0003818838,0.0002333028,0.0002620734],"domain_scores_gemma":[0.9990569,0.00004844345,0.0000930918,0.0004264283,0.0002970175,0.00007808861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008266384,0.000290605,0.000650102,0.0003867157,0.000093616,0.0001495364,0.00008169585,0.000001108668,0.9800988,0.00008510505,0.0037509,0.01432914],"study_design_scores_gemma":[0.0003116281,0.0000437114,0.009028329,0.0003092484,0.0001698157,0.0001310775,0.000138389,0.000136996,0.9867412,0.00001045325,0.00283608,0.000143046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868988,0.004917004,0.00002861081,0.005993072,0.000240679,0.0002763854,0.00005020521,0.00005754246,0.001537644],"genre_scores_gemma":[0.9927962,0.0001366739,0.005136775,0.0004899301,0.0001333804,6.729625e-7,0.00002599402,0.00002145148,0.001258921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0141861,"threshold_uncertainty_score":0.4926666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007371777696619832,"score_gpt":0.2306684973470539,"score_spread":0.223296719650434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}