{"id":"W3203481388","doi":"10.3390/molecules26196008","title":"Concise Large-Scale Synthesis of Tomatidine, A Potent Antibiotic Natural Product","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Natural product; Diosgenin; Combinatorial chemistry; Total synthesis; Chemistry; Prodrug; Stereochemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003180684,0.0006238799,0.0005453192,0.0005036516,0.0004411526,0.0002689763,0.000368536,0.0003630816,0.003319555],"category_scores_gemma":[0.0002295463,0.0002080659,0.0003261574,0.0004172444,0.0002503672,0.0005484327,0.0006739008,0.0006395494,0.00172589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002156778,"about_ca_system_score_gemma":0.0009349612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000399321,"about_ca_topic_score_gemma":0.001354513,"domain_scores_codex":[0.9998324,0.0000228028,0.00001810316,0.00003274394,0.00004771572,0.00004626337],"domain_scores_gemma":[0.9999224,0.00001122455,0.00001192958,0.00001237053,0.00001281376,0.00002934536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002795487,0.0005544215,0.0004114546,0.002001932,0.00009053859,0.002899348,0.0006047747,0.005151243,0.8957106,0.007733951,0.004898622,0.07966363],"study_design_scores_gemma":[0.0003233824,0.004563149,0.003486011,0.0001995029,0.0001737217,0.003338678,0.0003409356,0.006601322,0.8219793,0.005384036,0.1534299,0.0001800402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.652794,0.01897326,0.2338572,0.001360824,0.0008290341,0.002056158,0.00654379,0.002374157,0.08121154],"genre_scores_gemma":[0.9154689,0.01090453,0.05974012,0.0002114921,0.00008861146,0.0004959823,0.001936158,0.0001342943,0.01102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003319555,"threshold_uncertainty_score":0.01110506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007371777696619832,"score_gpt":0.2306684973470539,"score_spread":0.223296719650434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}