{"id":"W3203517331","doi":"10.1101/2021.10.01.462837","title":"Morphological control of receptor-mediated endocytosis","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Simon Fraser University; Michael Smith Health Research BC","keywords":"Endocytosis; Receptor-mediated endocytosis; Biophysics; Cell membrane; Membrane curvature; Internalization; Cell biology; Receptor; Endocytic cycle; Viral entry; Clathrin; Viral envelope; Membrane; Vesicle; Chemistry; Virus; Biology; Virology; Biochemistry; Viral replication","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001392631,0.0002499579,0.0001685052,0.0001575173,0.0001949415,0.0005640075,0.0003681059,0.0002775288,0.001034982],"category_scores_gemma":[0.0003955301,0.0001663302,0.0001766464,0.00009332321,0.0003448803,0.0002496704,0.0002372253,0.0002881014,0.0003517723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000642653,"about_ca_system_score_gemma":0.0001682026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005652172,"about_ca_topic_score_gemma":0.0003552296,"domain_scores_codex":[0.9998323,0.00001866834,0.000008328498,0.0000340952,0.00007194505,0.00003460943],"domain_scores_gemma":[0.9998088,0.00005494683,0.00005299017,0.00001986506,0.00003739898,0.00002585334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004485455,0.00000907875,0.0001079746,0.00002566509,0.000002402702,0.00004006069,0.000008662641,0.0005427771,0.9977399,0.0005962053,0.00004180019,0.0008406676],"study_design_scores_gemma":[0.00001035704,0.00003916914,0.001463672,0.000003307237,0.000002823913,0.00009086683,0.00001520041,0.00921984,0.9875777,0.0003046784,0.00126535,0.000007091927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776548,0.001204273,0.01398602,0.0002191728,0.00006867974,0.00003378774,0.0001627956,0.0001513767,0.006519233],"genre_scores_gemma":[0.9962479,0.0003515958,0.001939558,0.00002840113,0.000006701193,0.00001127401,0.00005604391,0.00002365596,0.001334896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001034982,"threshold_uncertainty_score":0.004662812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009794353031678546,"score_gpt":0.2161053578154908,"score_spread":0.2063110047838122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}