{"id":"W3203577554","doi":"10.1016/j.jaci.2021.08.030","title":"Efficacy and safety of benralizumab in chronic rhinosinusitis with nasal polyps: A randomized, placebo-controlled trial","year":2021,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Sinusitis and nasal conditions","field":"Medicine","cited_by":307,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Sanofi Genzyme; Argenx; Teva Pharmaceutical Industries; Regeneron Pharmaceuticals; Sanofi; Johns Hopkins University; Genentech; AstraZeneca","keywords":"Benralizumab; Medicine; Placebo; Nasal polyps; Randomized controlled trial; Internal medicine; Population; Gastroenterology; Asthma; Eosinophil; Surgery; Mepolizumab; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001028074,0.0001459788,0.001915014,0.0001528246,0.00005102225,0.00001134199,0.00006322288,0.000256629,0.0002475016],"category_scores_gemma":[0.001164695,0.00009817819,0.0003170255,0.0001361054,0.0005869491,0.00008020061,0.00004880445,0.0006350939,9.697693e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005038944,"about_ca_system_score_gemma":0.0007397422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003392845,"about_ca_topic_score_gemma":0.0002198632,"domain_scores_codex":[0.9972141,0.0006791654,0.00157775,0.000180815,0.0001598917,0.000188287],"domain_scores_gemma":[0.9964057,0.002460701,0.0006348319,0.0001480226,0.0002424996,0.0001083081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9901091,0.0006412486,0.0004067541,0.00001047018,0.00343796,0.0007058465,0.00009163928,0.000004621307,0.0004062471,0.001112082,0.00004631762,0.0030277],"study_design_scores_gemma":[0.9393368,0.006728803,0.05046663,0.0003701832,0.0004926252,0.00193788,0.0001177954,0.00003911143,0.00007271351,0.0001013644,0.0002445792,0.00009150548],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860414,0.01147025,0.00007597626,0.00118119,0.0003282027,0.0005257082,0.000003116862,0.000004474943,0.0003696342],"genre_scores_gemma":[0.9885207,0.0105057,0.0002934319,0.0001884469,0.0002799215,0.000008302838,0.000006267448,0.00001178749,0.0001854133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0507723,"threshold_uncertainty_score":0.4003591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597465083715579,"score_gpt":0.3173840202055638,"score_spread":0.3014093693684081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}