{"id":"W3203643115","doi":"10.1016/j.jconrel.2021.09.035","title":"Enzymatically releasable polyethylene glycol – host defense peptide conjugates with improved activity and biocompatibility","year":2021,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; British Columbia Knowledge Development Fund; Michael Smith Health Research BC","keywords":"Peptide; PEG ratio; Chemistry; Polyethylene glycol; PEGylation; Conjugate; Biocompatibility; In vitro; Cleavage (geology); Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003536396,0.0005689819,0.0002398565,0.0001755493,0.0001156609,0.0003965159,0.0002627611,0.0005018392,0.0007275517],"category_scores_gemma":[0.0003260526,0.0002021649,0.0002796804,0.0002236664,0.0002036461,0.000502512,0.0002272194,0.0006137207,0.0003772855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002102713,"about_ca_system_score_gemma":0.0001304976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001125046,"about_ca_topic_score_gemma":0.0001683801,"domain_scores_codex":[0.9998063,0.00003663825,0.00002328281,0.0000419893,0.00004130743,0.00005042129],"domain_scores_gemma":[0.9998289,0.0000355083,0.00005533998,0.00002560173,0.0000295577,0.00002512015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006741588,0.00002030698,0.00004359297,0.00002046857,0.000003804283,0.00005057847,0.00001163465,0.00008922614,0.9979637,0.00009123203,0.00001705152,0.001620997],"study_design_scores_gemma":[0.000009201555,0.0001894701,0.0003608464,0.000002022831,0.00001078274,0.0001394109,0.000003776455,0.0002504678,0.9981298,0.00001378957,0.0008869205,0.000003576219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830844,0.002008584,0.01294438,0.0001023145,0.00005402136,0.00004545031,0.00007806321,0.00009935879,0.001583396],"genre_scores_gemma":[0.9896515,0.0005854644,0.006776355,0.00008001412,0.00001706723,0.00003053489,0.0001748604,0.00002596494,0.002658098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007275517,"threshold_uncertainty_score":0.002433956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005883169716817321,"score_gpt":0.2112893636045453,"score_spread":0.2054061938877279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}