{"id":"W3203648464","doi":"10.21769/bioprotoc.4175","title":"Measuring Total Classical Pathway and Activities of Individual Components of the Mouse Complement Pathway","year":2021,"lang":"en","type":"article","venue":"BIO-PROTOCOL","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Health and Care Research Wales","keywords":"Complement (music); Complement system; Alternative complement pathway; Classical complement pathway; Biology; Innate immune system; Phagocytosis; Antibody; Complement component 5; Complement component 3; Cell biology; Immunology; Complement control protein; Hemolysis; Computational biology; Immune system; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001165937,0.001311477,0.0003909809,0.002031048,0.0003395639,0.0006278139,0.0005074834,0.0008223017,0.004761541],"category_scores_gemma":[0.0008516897,0.0003479618,0.0004936351,0.001064224,0.000449364,0.0005138306,0.0004990591,0.001891066,0.001717708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004083258,"about_ca_system_score_gemma":0.0004471839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004791115,"about_ca_topic_score_gemma":0.001122774,"domain_scores_codex":[0.9984978,0.000235739,0.0002160934,0.0003191075,0.0005368954,0.0001943349],"domain_scores_gemma":[0.9989954,0.0001454378,0.0002469993,0.0001492127,0.0003151969,0.0001477894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001901654,0.00008838594,0.0005195637,0.0001345014,0.00001602927,0.00002237237,0.00004030035,0.0000787645,0.9944801,0.0003300791,0.0002541017,0.003845663],"study_design_scores_gemma":[0.00001806851,0.0004552015,0.003785964,0.0000401707,0.00005284913,0.0001127811,0.00002158983,0.0005713732,0.9894493,0.0002523636,0.005224409,0.00001608557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7546262,0.008438183,0.1992053,0.0005299527,0.0004749987,0.002084636,0.01197299,0.002391928,0.02027569],"genre_scores_gemma":[0.6861528,0.01004915,0.2225458,0.0007889337,0.0001571798,0.007544991,0.02690918,0.0006877311,0.04516418],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.004761541,"threshold_uncertainty_score":0.01592898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07093139145479173,"score_gpt":0.2830985766070181,"score_spread":0.2121671851522264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}