{"id":"W3203648464","doi":"10.21769/bioprotoc.4175","title":"Measuring Total Classical Pathway and Activities of Individual Components of the Mouse Complement Pathway","year":2021,"lang":"en","type":"article","venue":"BIO-PROTOCOL","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Health and Care Research Wales","keywords":"Complement (music); Complement system; Alternative complement pathway; Classical complement pathway; Biology; Innate immune system; Phagocytosis; Antibody; Complement component 5; Complement component 3; Cell biology; Immunology; Complement control protein; Hemolysis; Computational biology; Immune system; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002363499,0.0001751351,0.0003499112,0.00005128366,0.000144453,0.00001625841,0.0002694678,0.00008915631,0.0005423492],"category_scores_gemma":[0.00005301083,0.0001294365,0.0001317655,0.00009156485,0.0003139103,0.00005224932,0.0006538036,0.0001308924,0.000007597264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003297432,"about_ca_system_score_gemma":0.000125573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003303968,"about_ca_topic_score_gemma":0.00003237293,"domain_scores_codex":[0.9983658,0.0004712936,0.0005029074,0.0002568908,0.0001566299,0.0002464491],"domain_scores_gemma":[0.9990487,0.0001350458,0.0002972028,0.000410851,0.00008171271,0.0000265036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001872497,0.0006057908,0.03312512,0.0003965249,0.0002445705,0.000002175229,0.0004013206,0.000001697186,0.9606254,0.001512108,0.0009652477,0.001932776],"study_design_scores_gemma":[0.002925363,0.0001441921,0.1036715,0.0001583952,0.00002369898,0.00002030284,0.0008761884,0.000001952485,0.8673925,0.00003896574,0.02460538,0.0001415404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8345661,0.000030787,0.000009163631,0.0000803139,0.0001341702,0.1639689,0.0007450443,0.00002977111,0.0004357935],"genre_scores_gemma":[0.821501,1.492352e-7,0.000036983,0.00001928848,0.00001805732,0.1781006,0.0000487335,0.00001141712,0.0002637574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09323293,"threshold_uncertainty_score":0.5938343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07093139145479173,"score_gpt":0.2830985766070181,"score_spread":0.2121671851522264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}