{"id":"W3203721135","doi":"10.1016/j.jacc.2021.08.009","title":"Comparative Reductions in Investigator-Reported and Adjudicated Ischemic Events in REDUCE-IT","year":2021,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Medicine; Clinical endpoint; Myocardial infarction; Concordance; Unstable angina; Internal medicine; Stroke (engine); Placebo; Cardiology; Randomized controlled trial; Surrogate endpoint; Revascularization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.007941633,0.0007613922,0.001996668,0.0004815124,0.0001914875,0.0008562886,0.0004340415,0.001035298,0.00192931],"category_scores_gemma":[0.009065736,0.0003847582,0.002093578,0.0004385282,0.0008480008,0.0005407417,0.000565515,0.001385477,0.0002995472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004083984,"about_ca_system_score_gemma":0.0005043377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003021256,"about_ca_topic_score_gemma":0.0005959964,"domain_scores_codex":[0.9947259,0.003714529,0.0003902735,0.0003709741,0.000538973,0.0002594359],"domain_scores_gemma":[0.9923349,0.003323414,0.002873864,0.0005491872,0.0004502403,0.0004683639],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9471695,0.002006385,0.01376824,0.001016561,0.003682435,0.00004339667,0.0001177787,0.0003843147,0.001940092,0.0001657642,0.0004182275,0.02928726],"study_design_scores_gemma":[0.6112029,0.2003968,0.1671053,0.0004243027,0.0121972,0.0002520104,0.0001927433,0.00174137,0.003754397,0.0006200859,0.002031691,0.00008119592],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883178,0.005207271,0.001120808,0.000254992,0.0001748814,0.0009982535,0.0006030725,0.00005853287,0.003264454],"genre_scores_gemma":[0.9960387,0.0009524613,0.0008663617,0.0002407625,0.000173033,0.0006800828,0.0006177402,0.000009608611,0.0004212936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9920584,"threshold_uncertainty_score":0.04199988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03573280280697685,"score_gpt":0.3194443340398711,"score_spread":0.2837115312328943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}