{"id":"W3203747240","doi":"10.30683/1927-7229.2019.08.03","title":"Boldine Activates Intrinsic Apoptotic Pathway in DU-145 Androgen-Independent Prostate Cancer Cell Line ","year":2019,"lang":"en","type":"article","venue":"Journal of Analytical Oncology","topic":"Traditional and Medicinal Uses of Annonaceae","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Apoptosis; Programmed cell death; Prostate cancer; Viability assay; Cancer research; Hsp70; Aporphine; Chemistry; Caspase; Cell growth; Cancer; Heat shock protein; Pharmacology; Biology; Cell biology; Alkaloid; Medicine; Biochemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009633078,0.0002980215,0.0003742131,0.000271788,0.0002429045,0.0002167409,0.0001737897,0.0002087451,0.001418854],"category_scores_gemma":[0.00008080373,0.000114708,0.0003508332,0.0003434409,0.000101984,0.0001505729,0.0001438928,0.00062209,0.0004153186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001570276,"about_ca_system_score_gemma":0.0001912025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001193786,"about_ca_topic_score_gemma":0.002146377,"domain_scores_codex":[0.9998311,0.00002765909,0.00001917668,0.00002631094,0.00006977269,0.00002604822],"domain_scores_gemma":[0.9999307,0.00001367216,0.00001269781,0.000007982233,0.00002012252,0.00001470126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003167305,0.0002547359,0.000742289,0.0003116966,0.00002516614,0.0002378889,0.00009386575,0.0001319094,0.9940502,0.0001191594,0.0003862147,0.003330218],"study_design_scores_gemma":[0.00008823963,0.002893568,0.01450254,0.00002164173,0.00008128659,0.001225699,0.0001274128,0.001814278,0.9713659,0.00009464185,0.007766413,0.00001836356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775144,0.01253266,0.003303851,0.0002427992,0.0001529987,0.0000890036,0.002197949,0.0001226454,0.003843758],"genre_scores_gemma":[0.9797058,0.006485644,0.004084253,0.0001702425,0.00004882751,0.0001474614,0.003784789,0.00001482429,0.005558133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001418854,"threshold_uncertainty_score":0.004746556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009653422176855112,"score_gpt":0.2688439576747727,"score_spread":0.2591905354979176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}