{"id":"W3203780103","doi":"10.1152/physrev.00005.2021","title":"Development of antifibrotic therapy for stricturing Crohn’s disease: lessons from randomized trials in other fibrotic diseases","year":2021,"lang":"en","type":"review","venue":"Physiological Reviews","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Natural Science Foundation of China; Crohn's and Colitis Foundation; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Medicine; Crohn's disease; Fibrosis; Randomized controlled trial; Disease; Internal medicine; Clinical trial; Inflammation; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01137236,0.0009176509,0.004692928,0.001413491,0.0002531281,0.001822701,0.001244229,0.002361763,0.003892799],"category_scores_gemma":[0.0186034,0.0003081938,0.003036351,0.002061907,0.0006626687,0.001905214,0.0006766146,0.003136844,0.0006578222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001220683,"about_ca_system_score_gemma":0.002696811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008153364,"about_ca_topic_score_gemma":0.00168546,"domain_scores_codex":[0.9965695,0.001850357,0.0006410491,0.0002931716,0.0005413319,0.0001045049],"domain_scores_gemma":[0.9844899,0.01273302,0.0009579262,0.0002311827,0.001300555,0.0002874286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.002608808,0.0001681234,0.0002683416,0.1440516,0.002883641,0.0001330237,0.0000759155,0.0003591233,0.0009443603,0.005324707,0.01920116,0.8239813],"study_design_scores_gemma":[0.008322589,0.004350168,0.004680608,0.2556854,0.0193332,0.001034268,0.0002472965,0.0006020184,0.001639425,0.01399331,0.6899982,0.0001134982],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001244948,0.998449,0.0001265333,0.0006261175,0.0003610372,0.00002873509,0.00002837549,0.000004244081,0.0002514693],"genre_scores_gemma":[0.00236533,0.9942959,0.0008272249,0.001649902,0.0004230093,0.0001366253,0.00005996442,0.000006606886,0.0002353602],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01137236,"threshold_uncertainty_score":0.06014347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2047268792548023,"score_gpt":0.4219387573494485,"score_spread":0.2172118780946462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}