{"id":"W3203783224","doi":"10.1161/circulationaha.121.056456","title":"Epigenetic Age and the Risk of Incident Atrial Fibrillation","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; McMaster University Medical Centre; McMaster University; Population Health Research Institute; Western University","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health","keywords":"Epigenetics; Atrial fibrillation; Risk factor; Disease; Senescence; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003004006,0.00005853894,0.00008893925,0.00001667171,0.0000647672,0.00001666354,0.00003077482,0.00007363205,0.000006753271],"category_scores_gemma":[0.0003462101,0.00004788943,0.00008827698,0.00006829592,0.00006776009,0.000002160442,0.00003955361,0.00003049884,0.000001053731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000554163,"about_ca_system_score_gemma":0.00003279183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002828767,"about_ca_topic_score_gemma":0.00003784138,"domain_scores_codex":[0.9993189,0.0001766185,0.0001853577,0.0001541722,0.0001012104,0.00006371378],"domain_scores_gemma":[0.9995017,0.0000446078,0.0001365263,0.0001974811,0.00009868975,0.00002097945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001139498,0.000006197956,0.427359,0.00002072925,0.00009038,0.000001536059,0.0002351921,0.02853614,0.515036,0.0009616806,0.000007742877,0.02763147],"study_design_scores_gemma":[0.001164764,0.00002340821,0.8812273,0.000006213731,0.00007895898,0.00000247428,0.00002936278,0.002830144,0.1084695,0.0045746,0.001509742,0.00008352427],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803557,0.008311948,0.01077181,0.00005568935,0.0001055248,0.0001263329,0.000004796091,0.000002816919,0.0002653714],"genre_scores_gemma":[0.9972537,0.001962976,0.0003440734,0.000009627542,0.0002896024,0.00000139278,0.0001032775,0.000007225008,0.00002819603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4538683,"threshold_uncertainty_score":0.1952874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085217685890123,"score_gpt":0.2480829819572507,"score_spread":0.2372308050983495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}