{"id":"W3203783224","doi":"10.1161/circulationaha.121.056456","title":"Epigenetic Age and the Risk of Incident Atrial Fibrillation","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; McMaster University Medical Centre; McMaster University; Population Health Research Institute; Western University","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health","keywords":"Epigenetics; Atrial fibrillation; Risk factor; Disease; Senescence; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002145086,0.0002567025,0.0003992841,0.0005934454,0.0001380467,0.0005624758,0.0002710688,0.0004094341,0.0009290945],"category_scores_gemma":[0.005367517,0.0001604284,0.001457016,0.0007347867,0.0002777771,0.0002544422,0.0003391138,0.0003940229,0.00005914901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002657201,"about_ca_system_score_gemma":0.000396369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001886388,"about_ca_topic_score_gemma":0.00151164,"domain_scores_codex":[0.999376,0.0003228545,0.00005613137,0.0001348386,0.00007945213,0.00003071976],"domain_scores_gemma":[0.9967566,0.001861193,0.0008933482,0.0002251334,0.0001829539,0.00008073796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002165357,0.00008402672,0.884962,0.002085959,0.02596883,0.0001520538,0.0001775024,0.003206111,0.001559706,0.001153189,0.0007854947,0.07769966],"study_design_scores_gemma":[0.0002695871,0.0008299031,0.9599308,0.0006571065,0.02400372,0.0005810949,0.00009872675,0.003860234,0.001225783,0.003851642,0.004663139,0.00002822522],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8045923,0.1843977,0.005735015,0.001356371,0.000212004,0.00004550409,0.001307785,0.00005789007,0.002295464],"genre_scores_gemma":[0.98195,0.01635628,0.0009570132,0.0001560168,0.0001127083,0.00002190583,0.0002550922,0.000004358707,0.0001866011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002145086,"threshold_uncertainty_score":0.01134443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085217685890123,"score_gpt":0.2480829819572507,"score_spread":0.2372308050983495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}