{"id":"W3203792140","doi":"10.1111/acel.13494","title":"Aging impairs human bone marrow function and cardiac repair following myocardial infarction in a humanized chimeric mouse","year":2021,"lang":"en","type":"article","venue":"Aging Cell","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Biology; Bone marrow; CD34; Myocardial infarction; Immunology; Haematopoiesis; Spleen; Stem cell; Heart failure; Andrology; Cardiac function curve; Immune system; Peripheral blood cell; Humanized mouse; Internal medicine; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005121559,0.0005875612,0.0003832878,0.0008597948,0.0001896362,0.0004651977,0.0003119028,0.0005853555,0.00206552],"category_scores_gemma":[0.0001347169,0.0002950775,0.000443848,0.0002539169,0.0003192651,0.0003345626,0.0003440052,0.0009352165,0.0005190448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002640079,"about_ca_system_score_gemma":0.0001930261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003608918,"about_ca_topic_score_gemma":0.000485872,"domain_scores_codex":[0.9996495,0.00005253398,0.00004420983,0.0001019476,0.00007241785,0.00007930716],"domain_scores_gemma":[0.9997583,0.00001650269,0.0001053601,0.00003155885,0.0000166799,0.00007154447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005403358,0.0001811967,0.0004994669,0.0000283345,0.00000930944,0.0001040351,0.00003809804,0.00005619646,0.9973282,0.00008620443,0.00005054159,0.001078025],"study_design_scores_gemma":[0.0002811178,0.007061175,0.04041246,0.00005218768,0.0001489244,0.002443796,0.0002754477,0.002284358,0.9393507,0.000271687,0.007385791,0.00003243025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958035,0.001109107,0.001722541,0.00009194625,0.00003709335,0.00005274402,0.0005819417,0.00006802495,0.0005331267],"genre_scores_gemma":[0.9920372,0.001026093,0.001923696,0.0001640918,0.00002397865,0.0001515389,0.001082533,0.0000373121,0.003553622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00206552,"threshold_uncertainty_score":0.006909847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00929915634743704,"score_gpt":0.2424964442472519,"score_spread":0.2331972878998149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}