{"id":"W3203802464","doi":"10.1021/acsinfecdis.1c00313","title":"Highly Potent Photoinactivation of Bacteria Using a Water-Soluble, Cell-Permeable, DNA-Binding Photosensitizer","year":2021,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Photosensitizer; Bacteria; DNA; Chemistry; Microbiology; Biophysics; Biochemistry; Biology; Photochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001568426,0.0003671402,0.0002182109,0.000135926,0.00009648357,0.00021899,0.0001606054,0.0003627896,0.0006375858],"category_scores_gemma":[0.0001320708,0.0001486181,0.0001523818,0.00009690929,0.0002030603,0.0002026623,0.0002552146,0.0003361718,0.0002476393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001629125,"about_ca_system_score_gemma":0.0001252005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003033382,"about_ca_topic_score_gemma":0.0007813624,"domain_scores_codex":[0.9998618,0.00002390321,0.000009625792,0.00003709723,0.00004695199,0.00002052047],"domain_scores_gemma":[0.9999088,0.00002921077,0.00003254386,0.00000699049,0.00001161731,0.0000109123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005481934,0.000002768226,0.00001391845,0.00002088137,6.653056e-7,0.00000765093,0.000004360757,0.00001646634,0.9994206,0.00001915302,0.000007187522,0.000480723],"study_design_scores_gemma":[0.000001494427,0.00005317073,0.0002525203,0.000002210635,0.000001358604,0.00005590124,0.000003973209,0.0001168873,0.9989091,0.000006743944,0.0005955365,0.00000113389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9482872,0.00564562,0.04168055,0.0001533897,0.00002996279,0.00006536323,0.0002252161,0.0002207666,0.003691766],"genre_scores_gemma":[0.978422,0.002160426,0.01640356,0.00007960266,0.000006241673,0.00004184688,0.0001995585,0.00003134348,0.00265526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006375858,"threshold_uncertainty_score":0.002132952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008305226716915328,"score_gpt":0.2014054228173396,"score_spread":0.1931001961004242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}