{"id":"W3203804374","doi":"10.1093/noajnl/vdab142","title":"Marizomib alone or in combination with bevacizumab in patients with recurrent glioblastoma: Phase I/II clinical trial data","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Celgene; Bristol-Myers Squibb","keywords":"Bevacizumab; Medicine; Internal medicine; Safety profile; Clinical trial; Phases of clinical research; Adverse effect; Oncology; Gastroenterology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002930759,0.000216758,0.0007381203,0.000169222,0.00006585896,0.000011588,0.0001542717,0.0001275673,0.00007537482],"category_scores_gemma":[0.0007981038,0.0001303551,0.00003614887,0.000542086,0.0001444607,0.0002899158,0.000173645,0.0003876612,0.000007853376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001598886,"about_ca_system_score_gemma":0.0004609488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008402504,"about_ca_topic_score_gemma":0.003159238,"domain_scores_codex":[0.9975933,0.0003550565,0.0006621626,0.0007637719,0.0003235024,0.0003021842],"domain_scores_gemma":[0.9981,0.0007911368,0.000258961,0.0005885625,0.0001378039,0.0001235023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3948887,0.05346359,0.2826997,0.00003827445,0.00008844459,0.004592602,0.00008921236,0.000012359,0.00004519716,0.00002881805,0.000532121,0.263521],"study_design_scores_gemma":[0.6989024,0.1515131,0.1141553,0.0002090755,0.0002424026,0.0001013129,0.0001023014,0.0001606353,0.0005000013,0.00003871735,0.03384753,0.0002272896],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949917,0.0003270315,0.000006864281,0.002466156,0.0006187182,0.001396078,0.00004259123,0.00002739282,0.0001234577],"genre_scores_gemma":[0.997212,0.0004257729,0.001075604,0.0005062761,0.00009346448,0.0001803109,0.0004642873,0.00002364604,0.00001865532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3040138,"threshold_uncertainty_score":0.5315728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0504961663408643,"score_gpt":0.3912912240822793,"score_spread":0.340795057741415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}