{"id":"W3203808599","doi":"10.1039/d1cs00098e","title":"The CRISPR–Cas toolbox for analytical and diagnostic assay development","year":2021,"lang":"en","type":"review","venue":"Chemical Society Reviews","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Brock University","funders":"National Natural Science Foundation of China","keywords":"Toolbox; CRISPR; Computational biology; Computer science; Biochemical engineering; Nanotechnology; Biology; Engineering; Genetics; Materials science; Programming language","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107253,0.001352192,0.001227565,0.003108753,0.0003001973,0.001425916,0.001391503,0.001639042,0.005183434],"category_scores_gemma":[0.001014411,0.0006367544,0.0006605466,0.002004305,0.0008957697,0.001517006,0.001206329,0.003398815,0.006550231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001182775,"about_ca_system_score_gemma":0.001657031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008409852,"about_ca_topic_score_gemma":0.001112528,"domain_scores_codex":[0.9992915,0.0001000407,0.00007206829,0.0001076848,0.0003717647,0.00005687983],"domain_scores_gemma":[0.999493,0.0002140105,0.00006344831,0.00003417913,0.0001309645,0.00006438138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003154413,0.00005429461,0.00009076288,0.007525357,0.00006673238,0.0002396722,0.00005339497,0.0009084901,0.01267238,0.01669312,0.05448779,0.9071764],"study_design_scores_gemma":[0.000006407334,0.00003194496,0.0001213567,0.0006195644,0.00002005846,0.000499698,0.00001050587,0.0001474997,0.002179177,0.002428608,0.9939177,0.00001740384],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002593262,0.9747027,0.01112964,0.001245453,0.0008895684,0.00005140158,0.0001561586,0.0003920493,0.01117381],"genre_scores_gemma":[0.002076148,0.9834384,0.007604164,0.0008250561,0.0003285617,0.00006129476,0.0003009433,0.00003463488,0.005330704],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005183434,"threshold_uncertainty_score":0.0173403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04046571633153342,"score_gpt":0.3876836592470642,"score_spread":0.3472179429155308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}