{"id":"W3203815137","doi":"10.1017/s0033291721003378","title":"Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation","year":2021,"lang":"en","type":"article","venue":"Psychological Medicine","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Holland Bloorview Kids Rehabilitation Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute on Drug Abuse; Medical Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; H. Lundbeck A/S; Université Paris-Sud; National Institute of Mental Health; Fondation pour la Recherche Médicale; ZonMw; Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives; Eli Lilly and Company; Science Foundation Ireland; European Commission; South London and Maudsley NHS Foundation Trust; University of Oxford; Fondation de France; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Institut National de la Santé et de la Recherche Médicale; EU Joint Programme – Neurodegenerative Disease Research; National Institutes of Health; Fondation de l'Avenir pour la Recherche Médicale Appliquée; Deutsche Forschungsgemeinschaft; King's College London","keywords":"Cannabis; Psychosis; Moderation; Schizophrenia (object-oriented programming); Psychology; Mediation; Psychiatry; Cohort; Clinical psychology; Polygenic risk score; Cannabis Dependence; Moderated mediation; Cohort study; Medicine; Internal medicine; Genetics; Single-nucleotide polymorphism; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002168854,0.0005870092,0.0004132074,0.0006597215,0.0005688592,0.0007848809,0.0006570222,0.0006966966,0.003922089],"category_scores_gemma":[0.006904734,0.0004158341,0.001359032,0.0006342106,0.0005475158,0.0003765964,0.001127019,0.0007332604,0.000184817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004737028,"about_ca_system_score_gemma":0.0009508419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01929832,"about_ca_topic_score_gemma":0.01746519,"domain_scores_codex":[0.9985455,0.0007470516,0.0000756165,0.0003181989,0.0001164983,0.0001971785],"domain_scores_gemma":[0.9957091,0.00235112,0.0006965445,0.0005348222,0.0001602312,0.0005482591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002855527,0.00005442587,0.9965179,0.00001474584,0.0006274531,0.0001015367,0.0001644868,0.0001021482,0.0003684711,0.0001331173,0.00004443381,0.001585738],"study_design_scores_gemma":[0.00001249495,0.0001591455,0.9978011,0.00001311859,0.0003188675,0.0001410457,0.000147925,0.0009340273,0.0001313685,0.0002223084,0.0001129229,0.0000056201],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984876,0.0003865262,0.0003625332,0.0001143957,0.00001211312,0.00001282182,0.0002663514,0.000006160024,0.0003514803],"genre_scores_gemma":[0.9993157,0.00008708117,0.0002344519,0.00001176098,0.000005952064,0.00001152398,0.0001377687,0.000002781667,0.0001928676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01929832,"threshold_uncertainty_score":0.03837198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03364847416085412,"score_gpt":0.318671188060638,"score_spread":0.285022713899784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}