{"id":"W3203815137","doi":"10.1017/s0033291721003378","title":"Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation","year":2021,"lang":"en","type":"article","venue":"Psychological Medicine","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Holland Bloorview Kids Rehabilitation Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute on Drug Abuse; Medical Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; H. Lundbeck A/S; Université Paris-Sud; National Institute of Mental Health; Fondation pour la Recherche Médicale; ZonMw; Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives; Eli Lilly and Company; Science Foundation Ireland; European Commission; South London and Maudsley NHS Foundation Trust; University of Oxford; Fondation de France; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; Institut National de la Santé et de la Recherche Médicale; EU Joint Programme – Neurodegenerative Disease Research; National Institutes of Health; Fondation de l'Avenir pour la Recherche Médicale Appliquée; Deutsche Forschungsgemeinschaft; King's College London","keywords":"Cannabis; Psychosis; Moderation; Schizophrenia (object-oriented programming); Psychology; Mediation; Psychiatry; Cohort; Clinical psychology; Polygenic risk score; Cannabis Dependence; Moderated mediation; Cohort study; Medicine; Internal medicine; Genetics; Single-nucleotide polymorphism; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00065235,0.0001412828,0.0003663708,0.0001824913,0.00005670592,0.00001352784,0.00003974793,0.0001466795,0.00006767365],"category_scores_gemma":[0.002438581,0.0001087842,0.00002494854,0.0002729941,0.0001870071,0.00008095495,0.00003353159,0.0002531355,3.189707e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007313598,"about_ca_system_score_gemma":0.00002335754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003318042,"about_ca_topic_score_gemma":0.000537624,"domain_scores_codex":[0.998255,0.0001310055,0.0005114551,0.0004766726,0.0003560218,0.0002698832],"domain_scores_gemma":[0.99932,0.00009026143,0.0001522391,0.0001646073,0.0001109793,0.0001619345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001257363,0.0003834662,0.9081839,0.00006857574,0.00002211882,0.0000381777,0.002840159,0.00003737866,0.05565386,0.00007129445,0.0002137603,0.03122995],"study_design_scores_gemma":[0.007097712,0.00106909,0.9819272,0.0001557381,0.00002782014,0.00009825757,0.001875899,0.006469181,0.0009101027,0.0002356757,0.00003501982,0.00009830942],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934161,0.001551533,0.001518301,0.002549531,0.0001189501,0.0007630353,0.00001048889,0.00001439216,0.00005767557],"genre_scores_gemma":[0.9970362,0.0007127139,0.001594717,0.0001078798,0.0001183473,0.0002581204,0.00003133829,0.0000139076,0.0001267982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07374329,"threshold_uncertainty_score":0.4436092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03364847416085412,"score_gpt":0.318671188060638,"score_spread":0.285022713899784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}