{"id":"W3203818267","doi":"10.1038/s41467-021-25951-3","title":"SPOP mutation induces DNA methylation via stabilizing GLP/G9a","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency; University of Toronto; University Health Network","funders":"National Natural Science Foundation of China; Mayo Clinic","keywords":"DNA methylation; Biology; Cancer research; Molecular biology; Ubiquitin ligase; DNA demethylation; Mutation; Methylation; Methyltransferase; Genetics; DNA; Ubiquitin; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005688844,0.0002125373,0.0001325821,0.0001633106,0.0001107765,0.0001238118,0.0001193676,0.0001943617,0.001118978],"category_scores_gemma":[0.00007940064,0.0001010746,0.0001824562,0.00008201148,0.000161551,0.00008256075,0.000174314,0.0002763865,0.0001648701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001881519,"about_ca_system_score_gemma":0.0001151283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004909894,"about_ca_topic_score_gemma":0.0009718376,"domain_scores_codex":[0.9999437,0.000007456828,0.000003788492,0.00001812819,0.00001404854,0.00001281396],"domain_scores_gemma":[0.9999473,0.00000613548,0.00002341818,0.000005733696,0.000003259107,0.00001423761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006516009,0.000007226854,0.000825983,0.00001867455,0.000007300433,0.0001100716,0.000004596937,0.00003782046,0.9978764,0.00003925946,0.00003217436,0.0009752617],"study_design_scores_gemma":[0.000008906955,0.0002298639,0.0153355,0.000004484314,0.00001678869,0.0008183692,0.00001703984,0.0005771894,0.981232,0.00004808208,0.001708744,0.000003062125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966079,0.0007995949,0.001520562,0.00007418007,0.00001316262,0.00001449852,0.000282793,0.0001014508,0.0005858014],"genre_scores_gemma":[0.9986182,0.0002520356,0.0004806903,0.00001907656,0.000002065023,0.000006526622,0.0001626796,0.000005981123,0.0004528063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001118978,"threshold_uncertainty_score":0.00374341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02318296890630466,"score_gpt":0.3219992253627922,"score_spread":0.2988162564564875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}