{"id":"W3203823955","doi":"10.1016/j.stemcr.2021.09.002","title":"Large-scale analysis of imprinting in naive human pluripotent stem cells reveals recurrent aberrations and a potential link to FGF signaling","year":2021,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; Rosetrees Trust","keywords":"Biology; Imprinting (psychology); Genomic imprinting; Induced pluripotent stem cell; DNA methylation; Reprogramming; Genetics; Embryonic stem cell; Epigenetics; Genomics; Computational biology; Gene; Genome; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001392341,0.0001171575,0.0001040415,0.0001787511,0.00008660009,0.0002045775,0.00008808695,0.0001077963,0.0006962758],"category_scores_gemma":[0.000233778,0.00008762382,0.0001030217,0.0001253413,0.0001363735,0.00008835262,0.0001763652,0.0002500737,0.0001610937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008044699,"about_ca_system_score_gemma":0.00008724363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002701552,"about_ca_topic_score_gemma":0.0004717134,"domain_scores_codex":[0.9999069,0.000009490297,0.000008654556,0.00002644062,0.00003661773,0.00001182123],"domain_scores_gemma":[0.9998928,0.00003235948,0.0000251846,0.00002240238,0.0000114949,0.00001582446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003106362,0.000004420358,0.002064502,0.0000106856,0.000003545603,0.00004053921,0.00001555518,0.00005431823,0.9958967,0.00003412413,0.000009517144,0.001834976],"study_design_scores_gemma":[0.000004083967,0.0001529617,0.07615716,0.000003647954,0.00002041764,0.0004920717,0.00004685578,0.00115533,0.9207698,0.0001492473,0.001043914,0.000004540263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991606,0.0004906383,0.006765067,0.00002620452,0.000005932541,0.00002375677,0.0005054834,0.00006537546,0.0005115514],"genre_scores_gemma":[0.9952481,0.0002409069,0.003169362,0.00002539864,0.000003253355,0.00002156151,0.000688041,0.00001693402,0.000586445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006962758,"threshold_uncertainty_score":0.00232929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009291860211971608,"score_gpt":0.2416699032465721,"score_spread":0.2323780430346005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}