{"id":"W3203824213","doi":"10.1172/jci152310","title":"Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Perelman School of Medicine, University of Pennsylvania; Center for AIDS Research, University of Washington; University of Pennsylvania; National Institute of Neurological Disorders and Stroke; BioNTech","keywords":"Titer; Immunization; Immune system; Antibody; Antigen; Sex organ; Messenger RNA; Immunity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006244843,0.0006376417,0.0006724836,0.0005710979,0.0001710831,0.0004160112,0.0004108241,0.0006412019,0.001450864],"category_scores_gemma":[0.0003475169,0.0002287456,0.0002773209,0.0002000028,0.0003837433,0.0004273537,0.0001591961,0.001332233,0.0003908037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000294766,"about_ca_system_score_gemma":0.0003528501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005173617,"about_ca_topic_score_gemma":0.0008278725,"domain_scores_codex":[0.9996889,0.00007291627,0.00002290715,0.00005217789,0.00005699842,0.0001062151],"domain_scores_gemma":[0.9997413,0.00004871782,0.00006852293,0.00004260134,0.00003616881,0.00006276819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001914999,0.00230114,0.0003462666,0.0001538989,0.00003359794,0.00006347145,0.00006605157,0.0004984672,0.9858359,0.0001612147,0.0002164554,0.008408498],"study_design_scores_gemma":[0.0005612689,0.06368291,0.003293486,0.00004571329,0.0001158359,0.0003235269,0.00006401505,0.001104736,0.9278975,0.0001482832,0.002750911,0.00001183069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939102,0.001567144,0.002385062,0.0001634819,0.0001220765,0.0001809692,0.0002703678,0.0001359127,0.001264859],"genre_scores_gemma":[0.9917703,0.001972008,0.002785186,0.0001251476,0.00006955636,0.0002669693,0.0006698379,0.00003419806,0.002306887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001450864,"threshold_uncertainty_score":0.004853606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1411948163975165,"score_gpt":0.3809080664430161,"score_spread":0.2397132500454996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}