{"id":"W3203851743","doi":"10.1016/j.jpba.2021.114379","title":"Process Analytical Technologies – Advances in bioprocess integration and future perspectives","year":2021,"lang":"en","type":"article","venue":"Journal of Pharmaceutical and Biomedical Analysis","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; Sanofi (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Bioprocess; Process analytical technology; Quality by Design; Process engineering; Process (computing); Biochemical engineering; Process control; Manufacturing engineering; Process development; Quality (philosophy); Biopharmaceutical; Critical quality attributes; Systems engineering; Computer science; Engineering; Biotechnology; Operations management","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001663794,0.0001078298,0.000250547,0.0002107308,0.00004979032,0.00003210139,0.00007786822,0.0001373436,0.00004961961],"category_scores_gemma":[0.0001749469,0.0000708505,0.0001231461,0.0007501706,0.0002741753,0.00002038988,0.00006486011,0.0001979299,2.119873e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008638942,"about_ca_system_score_gemma":0.00005660841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001027498,"about_ca_topic_score_gemma":0.000008514607,"domain_scores_codex":[0.9990967,0.000050344,0.0002885932,0.0002269241,0.0001988153,0.0001386546],"domain_scores_gemma":[0.9994669,0.00001825379,0.00009472116,0.00006553527,0.0002106266,0.0001439909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00124061,0.002466373,0.09937401,0.0004284895,0.002425764,0.0004566806,0.0007743308,0.00007605412,0.3076237,0.001579437,0.0008050717,0.5827495],"study_design_scores_gemma":[0.01102884,0.00448631,0.06730546,0.0005306706,0.007624076,0.002035684,0.09012771,0.02318645,0.5039036,0.0141252,0.2733268,0.002319225],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9374026,0.05662592,0.001482226,0.00427718,0.0000731742,0.00003124645,0.00000887653,0.000006673562,0.00009207887],"genre_scores_gemma":[0.9698955,0.02951288,0.0001789733,0.0001172506,0.0002592047,0.000002223478,0.000010007,0.000003522602,0.0000204757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5804303,"threshold_uncertainty_score":0.2889199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007747407702051177,"score_gpt":0.3384299110040814,"score_spread":0.3306825033020302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}