{"id":"W3203862576","doi":"10.3389/fnmol.2021.720973","title":"PRDM12 Is Transcriptionally Active and Required for Nociceptor Function Throughout Life","year":2021,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ludwig Boltzmann Gesellschaft; Austrian Science Fund; Österreichischen Akademie der Wissenschaften","keywords":"Neurogenesis; Nociceptor; Nociception; Neuroscience; Sensory system; Biology; Transcription factor; Nervous system; Loss function; Phenotype; Genetics; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000822902,0.0001181114,0.0001899586,0.00007030299,0.00008953139,0.00002914594,0.00005439527,0.00006115453,0.000009867605],"category_scores_gemma":[0.0001659336,0.0001149379,0.0000596558,0.000237499,0.00007069189,0.0001485981,0.00001847379,0.00007424905,7.64063e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004705439,"about_ca_system_score_gemma":0.0001485581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003549452,"about_ca_topic_score_gemma":0.000001199048,"domain_scores_codex":[0.9988932,0.00004043791,0.000137276,0.0004622696,0.0002440497,0.0002227864],"domain_scores_gemma":[0.9995986,0.000009328144,0.0000397913,0.0001665872,0.00006350687,0.0001221898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003206825,0.0002217889,0.002693587,0.00005372431,0.00002840022,0.0001640367,0.0003034785,0.000009488349,0.9865196,0.0008047391,0.002916438,0.005963996],"study_design_scores_gemma":[0.01533377,0.002963548,0.09544051,0.0002295864,0.0006581373,0.00021411,0.002041909,0.01597737,0.7524264,0.01412548,0.09963994,0.0009491884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1383341,0.0009329308,0.8537297,0.003862456,0.001692829,0.0007727615,0.00006045694,0.00004124448,0.0005735037],"genre_scores_gemma":[0.9172512,0.0001901989,0.06356852,0.01757087,0.0000623439,0.0001292012,0.00005287311,0.0000362188,0.001138633],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7901612,"threshold_uncertainty_score":0.468703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01951072188794651,"score_gpt":0.2773169560196373,"score_spread":0.2578062341316908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}