{"id":"W3203889005","doi":"10.1038/s41588-021-00935-7","title":"A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response","year":2021,"lang":"en","type":"article","venue":"Nature Genetics","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":187,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Public Health Agency of Canada; University of Ottawa; McGill University; University of Calgary; University of Saskatchewan; Université Laval; Université de Montréal; Providence Health Care Research Institute","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; Mississippi State Department of Health; National Institute of Environmental Health Sciences; Frederick National Laboratory for Cancer Research; National Institute of Diabetes and Digestive and Kidney Diseases; Jackson State University; Wake Forest University; American Diabetes Association; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Biology; Host (biology); Human immunodeficiency virus (HIV); Diversity (politics); Human leukocyte antigen; Population; Evolutionary biology; Computational biology; Genetics; Resolution (logic); High resolution; Virology; Remote sensing; Environmental health; Antigen; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001134287,0.0003212549,0.000421049,0.001056626,0.0003727088,0.0009512319,0.0005621468,0.0006891451,0.001997396],"category_scores_gemma":[0.001366385,0.0003654038,0.0003289544,0.0009824651,0.0002012608,0.0003606956,0.0007603104,0.0008049714,0.0006841185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001938537,"about_ca_system_score_gemma":0.000210576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001635829,"about_ca_topic_score_gemma":0.003321815,"domain_scores_codex":[0.9994642,0.000135925,0.00002631493,0.0002026061,0.0001016151,0.00006935184],"domain_scores_gemma":[0.9994321,0.0001611844,0.00006351661,0.0001999893,0.00009694516,0.00004616932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004838971,0.0001555773,0.06226834,0.00009469056,0.0002923506,0.0003035107,0.0002896829,0.008440812,0.8020268,0.002630784,0.002750989,0.1202625],"study_design_scores_gemma":[0.0001975881,0.0009192433,0.5519507,0.0001292034,0.0009947488,0.004455931,0.000452449,0.07893544,0.3080853,0.01044059,0.04326214,0.0001768146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8447133,0.001617982,0.1419506,0.0002745136,0.00008915247,0.00005872837,0.005630417,0.0006354179,0.005029828],"genre_scores_gemma":[0.9302037,0.0004827524,0.06123364,0.0003103539,0.00005410679,0.00007032965,0.005336547,0.0001406863,0.002167929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001997396,"threshold_uncertainty_score":0.006681919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03401265512755876,"score_gpt":0.2512860280858559,"score_spread":0.2172733729582972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}