{"id":"W3203941551","doi":"10.1002/prp2.846","title":"Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic","year":2021,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Actelion Pharmaceuticals","keywords":"Bioequivalence; Tadalafil; Medicine; Pharmacology; Pharmacokinetics; Adverse effect; Crossover study; Confidence interval; Bioavailability; Dosing; Coronavirus disease 2019 (COVID-19); Fixed-dose combination; Internal medicine; Sildenafil","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00246258,0.0001229385,0.0003433607,0.0002872704,0.0001202014,0.00001159088,0.0001028933,0.00007817076,0.0001024366],"category_scores_gemma":[0.0009601557,0.00009226083,0.00005083262,0.0005609147,0.001090999,0.0001044376,0.00009247092,0.0003319086,7.180348e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001128341,"about_ca_system_score_gemma":0.0003147109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001223616,"about_ca_topic_score_gemma":0.00003919438,"domain_scores_codex":[0.9970055,0.001803131,0.0002213236,0.0003396568,0.0003528381,0.0002775603],"domain_scores_gemma":[0.995976,0.003379727,0.00007717304,0.0001301858,0.0003054414,0.0001315137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004148214,0.000923393,0.6612808,0.0006137927,0.0004442458,0.0001499308,0.04189926,0.00001682704,0.2797141,0.005970412,0.0008220337,0.004016974],"study_design_scores_gemma":[0.02068022,0.01427778,0.7683715,0.000226414,0.0004567309,0.0008397493,0.03819251,0.003907212,0.1458486,0.006658161,0.0002200799,0.0003210489],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781746,0.01824015,0.0001394842,0.002241171,0.00003182452,0.0009397421,0.00001627948,0.00001333386,0.0002034555],"genre_scores_gemma":[0.9964404,0.003118859,0.0001140612,0.0001040055,0.00003766,0.00007928858,0.000005452679,0.00001023459,0.00009008737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1338654,"threshold_uncertainty_score":0.4019831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1753969610226535,"score_gpt":0.4501615824634102,"score_spread":0.2747646214407568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}