{"id":"W3203941551","doi":"10.1002/prp2.846","title":"Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic","year":2021,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Actelion Pharmaceuticals","keywords":"Bioequivalence; Tadalafil; Medicine; Pharmacology; Pharmacokinetics; Adverse effect; Crossover study; Confidence interval; Bioavailability; Dosing; Coronavirus disease 2019 (COVID-19); Fixed-dose combination; Internal medicine; Sildenafil","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01334812,0.0008665109,0.001908252,0.0004729666,0.0002404688,0.0006779549,0.001056371,0.001033497,0.002464411],"category_scores_gemma":[0.01068919,0.0006248832,0.001261793,0.000394043,0.001453483,0.0004998968,0.0006701706,0.001677565,0.0002210005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007983167,"about_ca_system_score_gemma":0.0008442735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005070816,"about_ca_topic_score_gemma":0.000303545,"domain_scores_codex":[0.9894915,0.008291676,0.0004405759,0.0008845537,0.0006018252,0.0002898939],"domain_scores_gemma":[0.9936093,0.003178802,0.00154208,0.001019616,0.000365596,0.0002845871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8483769,0.02420056,0.006512722,0.0005798399,0.001406599,0.00008496309,0.0004329933,0.01344385,0.04523921,0.001358237,0.0004099021,0.05795411],"study_design_scores_gemma":[0.09577308,0.8187874,0.02196485,0.00005246698,0.001324157,0.00008695447,0.0001085581,0.0401361,0.01757821,0.001319898,0.002731956,0.0001363148],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880938,0.0001925407,0.007702995,0.00007045268,0.00009506627,0.003252772,0.0001354339,0.00004202006,0.0004149498],"genre_scores_gemma":[0.9755533,0.0001549,0.01715444,0.0001437496,0.00006530144,0.006020758,0.0001169853,0.000020096,0.0007704869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01334812,"threshold_uncertainty_score":0.07059246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1753969610226535,"score_gpt":0.4501615824634102,"score_spread":0.2747646214407568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}