{"id":"W3203954801","doi":"10.1161/hypertensionaha.120.16712","title":"Peptide Blocking Self-Polymerization of Extracellular Calcium-Sensing Receptor Attenuates Hypoxia-Induced Pulmonary Hypertension","year":2021,"lang":"en","type":"article","venue":"Hypertension","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Key Research and Development Program of China; National Institutes of Health; Tongji University; National Natural Science Foundation of China","keywords":"Extracellular; Hypoxia (environmental); Pulmonary hypertension; Receptor; Chemistry; Calcium; Blocking (statistics); Calcium-sensing receptor; Internal medicine; Pharmacology; Endocrinology; Medicine; Biophysics; Cell biology; Biochemistry; Biology; Calcium metabolism; Oxygen; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439916,0.0002321567,0.0003839997,0.00005687793,0.0001351413,0.00002191039,0.0001074571,0.0002583195,0.00004041736],"category_scores_gemma":[0.0002664785,0.0002137145,0.0002592268,0.0002636477,0.00004194741,0.000008424032,0.0001509889,0.000110156,0.00001413454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001762514,"about_ca_system_score_gemma":0.00006006308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004402444,"about_ca_topic_score_gemma":0.000004034646,"domain_scores_codex":[0.9983557,0.0001069076,0.0004182398,0.000571462,0.0002638921,0.00028383],"domain_scores_gemma":[0.9988155,0.00004695653,0.0001751048,0.0004827275,0.0003692027,0.0001104458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003262739,0.0001835496,0.0005579813,0.00002963399,0.0000839768,0.00004636632,0.00001382221,0.00001761274,0.9903584,0.00000482644,0.0005036998,0.00816757],"study_design_scores_gemma":[0.0002400206,0.00004635223,0.0005123027,0.0001055748,0.0001465029,0.0001731635,0.0001300787,0.003889603,0.9892568,0.00001051131,0.005217265,0.0002718304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959362,0.002676055,0.0005153745,0.0003243254,0.0001402289,0.00007782848,0.00000689289,0.00003316098,0.0002899362],"genre_scores_gemma":[0.9956438,0.0004337411,0.002767474,0.000231791,0.0002760114,0.000002063216,0.0003220094,0.00004490673,0.0002782039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007895739,"threshold_uncertainty_score":0.8715024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02171925424483337,"score_gpt":0.221614655876316,"score_spread":0.1998954016314826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}