{"id":"W3203954801","doi":"10.1161/hypertensionaha.120.16712","title":"Peptide Blocking Self-Polymerization of Extracellular Calcium-Sensing Receptor Attenuates Hypoxia-Induced Pulmonary Hypertension","year":2021,"lang":"en","type":"article","venue":"Hypertension","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Key Research and Development Program of China; National Institutes of Health; Tongji University; National Natural Science Foundation of China","keywords":"Extracellular; Hypoxia (environmental); Pulmonary hypertension; Receptor; Chemistry; Calcium; Blocking (statistics); Calcium-sensing receptor; Internal medicine; Pharmacology; Endocrinology; Medicine; Biophysics; Cell biology; Biochemistry; Biology; Calcium metabolism; Oxygen; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001367278,0.0003297957,0.0004650623,0.0001310166,0.00009144926,0.0001611559,0.0002614275,0.0003096661,0.001183348],"category_scores_gemma":[0.0001512245,0.0001116938,0.0001720074,0.00007277983,0.0002024124,0.000191839,0.00009341813,0.0008021902,0.0002089478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001099991,"about_ca_system_score_gemma":0.0001679065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002002157,"about_ca_topic_score_gemma":0.0002563039,"domain_scores_codex":[0.9999141,0.00001644645,0.00000890515,0.00001462257,0.00001650713,0.00002944503],"domain_scores_gemma":[0.9998938,0.00002219435,0.00002872387,0.000008464159,0.00001057043,0.00003618965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008579173,0.0003611071,0.00007403393,0.00006610606,0.00001221718,0.00005011924,0.000011652,0.0001006562,0.9956725,0.00008517574,0.00009380936,0.002614801],"study_design_scores_gemma":[0.0002930317,0.006381021,0.00217725,0.000009808564,0.00005683774,0.0002877935,0.00001572636,0.001798084,0.9868791,0.00004580427,0.002048519,0.000007135141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996036,0.001312017,0.001438071,0.0001358757,0.00008450796,0.00004520659,0.00007776779,0.00008056602,0.0007901128],"genre_scores_gemma":[0.9955439,0.001111105,0.001336548,0.00007586492,0.00005579107,0.00005963185,0.0002086249,0.00001363438,0.001594898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001183348,"threshold_uncertainty_score":0.003958762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02171925424483337,"score_gpt":0.221614655876316,"score_spread":0.1998954016314826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}