{"id":"W3204045414","doi":"10.1182/bloodadvances.2021005682","title":"Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma","year":2021,"lang":"en","type":"article","venue":"Blood Advances","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Cancer Institute","keywords":"BCL6; Cancer research; Lymphoma; Biology; Ubiquitin ligase; Molecular biology; B cell; Gene; Genetics; Ubiquitin; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001902888,0.0002164854,0.0001886184,0.0002291188,0.00009206251,0.0003088609,0.0001232564,0.0003049239,0.0008384355],"category_scores_gemma":[0.0001295802,0.00007656252,0.00008389365,0.0001592438,0.0001570944,0.0002152776,0.0001949936,0.0003968079,0.0002593652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002088885,"about_ca_system_score_gemma":0.00007532668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001344842,"about_ca_topic_score_gemma":0.0002453426,"domain_scores_codex":[0.999936,0.00001923291,0.000006095123,0.000009717823,0.0000152767,0.00001374398],"domain_scores_gemma":[0.9999602,0.00001064045,0.000009976257,0.000004785529,0.000005556511,0.000008822011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007448993,0.0001337512,0.002071157,0.0002084916,0.00001850262,0.001171216,0.00004926221,0.0004207338,0.9108143,0.001951282,0.0007453391,0.08167104],"study_design_scores_gemma":[0.0003991009,0.002668299,0.01363834,0.00009330015,0.0001026744,0.01643104,0.00008884933,0.002837002,0.841074,0.00162087,0.1210274,0.00001908258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8824605,0.09111737,0.01178448,0.002488582,0.000191851,0.00009483068,0.0001947054,0.0003086458,0.01135903],"genre_scores_gemma":[0.9791854,0.01395799,0.003124481,0.0002470693,0.00007980331,0.00002768414,0.0001411157,0.00001601091,0.003220456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008384355,"threshold_uncertainty_score":0.002804816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009868486249774931,"score_gpt":0.2757344045850493,"score_spread":0.2658659183352743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}