{"id":"W3204168235","doi":"10.1016/j.biopha.2021.112230","title":"Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potential","year":2021,"lang":"en","type":"review","venue":"Biomedicine & Pharmacotherapy","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"National Science Foundation","keywords":"Cytokine storm; Metformin; PI3K/AKT/mTOR pathway; AMPK; Medicine; Diabetes mellitus; Proinflammatory cytokine; Immunology; Immunosuppression; Pharmacology; Signal transduction; Coronavirus disease 2019 (COVID-19); Inflammation; Internal medicine; Biology; Disease; Endocrinology; Protein kinase A; Cell biology; Kinase; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004368421,0.0006488764,0.001210978,0.001222727,0.0001740833,0.000685752,0.0007861254,0.0009617799,0.003192835],"category_scores_gemma":[0.0007082307,0.0001804262,0.00078355,0.0008809814,0.0002575414,0.0005941701,0.0003515168,0.001580686,0.0007568446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003503988,"about_ca_system_score_gemma":0.000553127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000626241,"about_ca_topic_score_gemma":0.001289641,"domain_scores_codex":[0.999892,0.00002871839,0.00002079382,0.00002088469,0.00002534602,0.00001229277],"domain_scores_gemma":[0.9997672,0.0001381801,0.00003255099,0.000006513626,0.00004071471,0.00001471265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003666321,0.0002066653,0.0002635512,0.02101485,0.0003259709,0.0001430666,0.00003388131,0.0002833068,0.0008647396,0.002283806,0.01696492,0.9572486],"study_design_scores_gemma":[0.0004623847,0.0009893352,0.004114734,0.01752667,0.001291723,0.002244344,0.00009587967,0.0004495554,0.001490754,0.003452281,0.9678276,0.00005478472],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002155165,0.999008,0.00004092907,0.0002180611,0.0001128117,0.000005133384,0.00001741265,0.000004159406,0.0003780192],"genre_scores_gemma":[0.001640795,0.9975525,0.0001389707,0.000219325,0.0001373988,0.00001299545,0.00003534989,0.00000135134,0.0002613905],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003192835,"threshold_uncertainty_score":0.01068109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1225189773141977,"score_gpt":0.5257860744785967,"score_spread":0.4032670971643991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}