{"id":"W3204182376","doi":"10.3233/jnd-210696","title":"Interrogation of Dystrophin and Dystroglycan Complex Protein Turnover After Exon Skipping Therapy","year":2021,"lang":"en","type":"article","venue":"Journal of Neuromuscular Diseases","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Duchenne Parent Project; Parent Project Muscular Dystrophy; Muscular Dystrophy Association; National Institute of Neurological Disorders and Stroke; Foundation to Eradicate Duchenne; U.S. Department of Defense","keywords":"Dystrophin; Duchenne muscular dystrophy; Exon skipping; mdx mouse; Utrophin; Muscular dystrophy; Protein turnover; Molecular biology; Biology; Internal medicine; Exon; Endocrinology; Medicine; Biochemistry; Protein biosynthesis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002499486,0.0002480746,0.0002775331,0.0002632248,0.0001386145,0.0002984813,0.0001962786,0.0003150846,0.0005745703],"category_scores_gemma":[0.0001969034,0.000132221,0.0001901994,0.0001869811,0.0001956379,0.0001818188,0.0001447955,0.00032372,0.0001943463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00034265,"about_ca_system_score_gemma":0.000171527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001177167,"about_ca_topic_score_gemma":0.001433559,"domain_scores_codex":[0.9998454,0.00001086003,0.000007584455,0.00004997312,0.00006498874,0.00002117089],"domain_scores_gemma":[0.9998834,0.00002331716,0.00004472441,0.00001037671,0.00002178096,0.000016339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006230767,0.00001174669,0.0009703497,0.00001935237,0.000009511659,0.00002276217,0.00001793988,0.0001960359,0.9969984,0.00004648914,0.00002167259,0.001623451],"study_design_scores_gemma":[0.000003825094,0.00024113,0.0250296,0.000004278471,0.00002845333,0.0001446252,0.00003454605,0.007665089,0.9655715,0.00007852292,0.001189675,0.000008795865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867605,0.001240632,0.01079903,0.00002920774,0.000009415745,0.00001980119,0.0004860948,0.0001102539,0.0005449364],"genre_scores_gemma":[0.9917772,0.0008348096,0.00472232,0.000044151,0.000003552021,0.00005304673,0.0005656269,0.00004299404,0.001956299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177167,"threshold_uncertainty_score":0.00248611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01047596193759671,"score_gpt":0.237320534429189,"score_spread":0.2268445724915923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}