{"id":"W3204182376","doi":"10.3233/jnd-210696","title":"Interrogation of Dystrophin and Dystroglycan Complex Protein Turnover After Exon Skipping Therapy","year":2021,"lang":"en","type":"article","venue":"Journal of Neuromuscular Diseases","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Duchenne Parent Project; Parent Project Muscular Dystrophy; Muscular Dystrophy Association; National Institute of Neurological Disorders and Stroke; Foundation to Eradicate Duchenne; U.S. Department of Defense","keywords":"Dystrophin; Duchenne muscular dystrophy; Exon skipping; mdx mouse; Utrophin; Muscular dystrophy; Protein turnover; Molecular biology; Biology; Internal medicine; Exon; Endocrinology; Medicine; Biochemistry; Protein biosynthesis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004932774,0.0001030599,0.0001749725,0.00003970422,0.00002769228,0.0000135665,0.00008035554,0.00004937202,0.0000450651],"category_scores_gemma":[0.00006321457,0.00008755308,0.0001694903,0.00005142173,0.00008541766,0.00001091607,0.00005099584,0.00007326067,2.965486e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004967741,"about_ca_system_score_gemma":0.00009651265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002175748,"about_ca_topic_score_gemma":0.000003791787,"domain_scores_codex":[0.9992537,0.0001306189,0.0002475488,0.0001463373,0.0001206935,0.0001011085],"domain_scores_gemma":[0.9994068,0.000008692982,0.0001982833,0.0001540559,0.0001555656,0.00007656412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007228954,0.0001732293,0.004176167,0.00004710651,0.0001056436,0.00004793485,0.00003338778,0.0000401811,0.9932431,0.0000142009,0.00007341264,0.001322736],"study_design_scores_gemma":[0.002601841,0.001481761,0.777095,0.0001369289,0.00009913312,0.0001435712,0.0003109342,0.00004188227,0.2143721,0.000424876,0.003059919,0.0002319873],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953548,0.0041079,0.000218115,0.0001434054,0.00005966765,0.00007684741,0.00001393781,0.000001999822,0.00002337867],"genre_scores_gemma":[0.9992358,0.0002519335,0.0001657416,0.0001808818,0.0001117749,0.000004563686,0.00002143055,0.00001120386,0.00001666703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.778871,"threshold_uncertainty_score":0.3570311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01047596193759671,"score_gpt":0.237320534429189,"score_spread":0.2268445724915923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}