{"id":"W3204197661","doi":"10.1039/d1cc04556c","title":"2,2′-Bipyridine-α,α′-trifluoromethyl-diol ligand: synthesis and application in the asymmetric Et<sub>2</sub>Zn alkylation of aldehydes","year":2021,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Centre in Green Chemistry and Catalysis; Université Laval","keywords":"Chemistry; Ligand (biochemistry); Steric effects; Trifluoromethyl; Bipyridine; Stereoselectivity; Enantiomer; Diol; Alkylation; Medicinal chemistry; Stereochemistry; Chiral ligand; Alcohol; Enantioselective synthesis; Catalysis; Organic chemistry; Crystal structure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001986939,0.0004492193,0.0002368373,0.000170317,0.0001732728,0.0001598246,0.0004329566,0.0003832918,0.0009967948],"category_scores_gemma":[0.000102511,0.0001391069,0.0001355855,0.0001871666,0.0001588592,0.0001909604,0.0001797998,0.0002853277,0.0006531451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005089896,"about_ca_system_score_gemma":0.0002985673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001552971,"about_ca_topic_score_gemma":0.002455955,"domain_scores_codex":[0.9999052,0.00001405783,0.000005386811,0.00002224442,0.0000172766,0.00003578399],"domain_scores_gemma":[0.9999557,0.000004197634,0.00001240407,0.000003321742,0.000007458952,0.00001697367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001850173,0.00004349822,0.00009883805,0.0001526612,0.000005355602,0.0001514402,0.00004178857,0.0004853728,0.9902195,0.0003657324,0.0002287111,0.008022124],"study_design_scores_gemma":[0.00004560691,0.0003876598,0.0006070121,0.000008484292,0.00001225201,0.0004407314,0.00002128909,0.001251623,0.9911396,0.00003949103,0.006029329,0.00001686997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9523532,0.004036212,0.03364794,0.0004088286,0.00005494786,0.0001224658,0.0006971954,0.0006048495,0.008074361],"genre_scores_gemma":[0.9761125,0.002048165,0.01736395,0.0001175161,0.00001802405,0.00007078386,0.0004442726,0.00003953996,0.003785213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001552971,"threshold_uncertainty_score":0.003693044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07271364459316425,"score_gpt":0.3945225794835727,"score_spread":0.3218089348904084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}