{"id":"W3204209229","doi":"10.1016/j.annonc.2021.08.2131","title":"LBA7 Nivolumab (NIVO) plus chemotherapy (Chemo) or ipilimumab (IPI) vs chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): CheckMate 649 study","year":2021,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal","funders":"Bristol-Myers Squibb","keywords":"Medicine; Nivolumab; Gastroesophageal Junction; Ipilimumab; Cancer; Internal medicine; Esophageal cancer; Oncology; Chemotherapy; Adenocarcinoma; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007348505,0.0006828926,0.001710515,0.0002386843,0.0002207067,0.0008637289,0.0006386297,0.0008885534,0.004663814],"category_scores_gemma":[0.000803817,0.0003219868,0.003075937,0.0003428849,0.0003474917,0.0005538138,0.0003089106,0.00187088,0.0007360223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006785975,"about_ca_system_score_gemma":0.0006592388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00167124,"about_ca_topic_score_gemma":0.00484037,"domain_scores_codex":[0.9997812,0.00008639421,0.00001442823,0.00005190071,0.00001859044,0.00004754046],"domain_scores_gemma":[0.9995479,0.0001468939,0.0001002369,0.00003747454,0.00002830386,0.0001391965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9101829,0.004739371,0.0146389,0.002745475,0.01426238,0.00009551413,0.00008016937,0.001065528,0.004236584,0.0003115676,0.003116622,0.04452491],"study_design_scores_gemma":[0.6455986,0.2175551,0.07039225,0.0008395576,0.05134343,0.0002940046,0.0002423512,0.002136445,0.002727048,0.0007260387,0.008058803,0.0000863931],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784943,0.01517928,0.0001793053,0.0004907761,0.00041238,0.0003082975,0.002048087,0.00004365272,0.002844009],"genre_scores_gemma":[0.987662,0.005409925,0.0003415231,0.001034147,0.0003036751,0.0002851953,0.002486179,0.00001720606,0.002460267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004663814,"threshold_uncertainty_score":0.01560205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1153346183679117,"score_gpt":0.445260752265614,"score_spread":0.3299261338977023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}