{"id":"W3204272926","doi":"10.1016/s2352-3026(21)00271-4","title":"Intralesional TTI-621, a novel biologic targeting the innate immune checkpoint CD47, in patients with relapsed or refractory mycosis fungoides or Sézary syndrome: a multicentre, phase 1 study","year":2021,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Cutaneous lymphoproliferative disorders research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"Medicine; Mycosis fungoides; Refractory (planetary science); Internal medicine; Cohort; Adverse effect; Gastroenterology; Surgery; Dermatology; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001102008,0.001385041,0.001884819,0.0003112535,0.0002842829,0.0009360589,0.000629439,0.001132432,0.001804003],"category_scores_gemma":[0.0005920705,0.0004185446,0.001335702,0.0003929667,0.0007837423,0.000793046,0.0002607706,0.002293273,0.0005652593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005545121,"about_ca_system_score_gemma":0.0006836623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007789673,"about_ca_topic_score_gemma":0.002134497,"domain_scores_codex":[0.9997144,0.0001184482,0.0000127574,0.00004802531,0.00002871696,0.00007754637],"domain_scores_gemma":[0.9996309,0.00007431856,0.0000699005,0.0000373153,0.0000196958,0.0001677586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6899253,0.03404349,0.01219712,0.001744689,0.003162,0.000507378,0.0005229522,0.003268999,0.07918631,0.0003586201,0.004002004,0.1710812],"study_design_scores_gemma":[0.5398129,0.4188997,0.03118267,0.00008100612,0.00157818,0.0005338757,0.0001563839,0.001398004,0.00344365,0.0002663554,0.002581148,0.00006608351],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947309,0.00312622,0.0002385261,0.0002319839,0.00007615963,0.0003567898,0.0003496991,0.00005067687,0.0008389289],"genre_scores_gemma":[0.9925089,0.00284283,0.0006130183,0.0006783067,0.0001203387,0.0005929455,0.001118134,0.00002305222,0.001502343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884819,"threshold_uncertainty_score":0.00603497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04827010800737181,"score_gpt":0.3387986010248302,"score_spread":0.2905284930174584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}