{"id":"W3204272926","doi":"10.1016/s2352-3026(21)00271-4","title":"Intralesional TTI-621, a novel biologic targeting the innate immune checkpoint CD47, in patients with relapsed or refractory mycosis fungoides or Sézary syndrome: a multicentre, phase 1 study","year":2021,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Cutaneous lymphoproliferative disorders research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"Medicine; Mycosis fungoides; Refractory (planetary science); Internal medicine; Cohort; Adverse effect; Gastroenterology; Surgery; Dermatology; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009733809,0.0003423683,0.001300908,0.000149341,0.0002632105,0.0000346494,0.0004359038,0.0001519611,0.0005142156],"category_scores_gemma":[0.002930185,0.0001510455,0.00008972969,0.0006981773,0.0004151969,0.0000638424,0.0003695086,0.0008007723,0.00004130409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001606724,"about_ca_system_score_gemma":0.0005578239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001216667,"about_ca_topic_score_gemma":0.000620439,"domain_scores_codex":[0.9965171,0.0008926166,0.0007108624,0.0005951034,0.0004844821,0.0007998949],"domain_scores_gemma":[0.9973001,0.001163822,0.0002516671,0.0008234999,0.0003600647,0.0001008498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05745101,0.01579516,0.8877351,0.0004936292,0.001016158,0.01362581,0.008385384,0.00004293592,0.01257184,0.00009919602,0.0009024167,0.001881362],"study_design_scores_gemma":[0.1026525,0.01294369,0.8346498,0.001005681,0.0004758215,0.01804951,0.02192831,0.001582139,0.004230801,0.0001430452,0.001362214,0.0009765082],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924722,0.0009130363,0.00002658372,0.004137565,0.0001067829,0.002161102,0.00004664008,0.0000599749,0.00007609319],"genre_scores_gemma":[0.9973027,0.000212451,0.0005769348,0.000970698,0.00005511229,0.000279843,0.0001361624,0.00004737802,0.000418742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0530853,"threshold_uncertainty_score":0.6159458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04827010800737181,"score_gpt":0.3387986010248302,"score_spread":0.2905284930174584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}