{"id":"W3204313672","doi":"10.2139/ssrn.3933294","title":"Topological Analysis of Single-Cell Hierarchy Reveals Inflammatory Glial Landscape of Macular Degeneration","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mila - Quebec Artificial Intelligence Institute; Institute of Infection and Immunity","funders":"","keywords":"Hierarchy; Topology (electrical circuits); Degeneration (medical); Neuroscience; Physics; Biology; Medicine; Mathematics; Pathology; Combinatorics; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005494903,0.0001246064,0.0002911276,0.0001153687,0.00006104651,0.00001420398,0.000158038,0.0001691419,0.00004392629],"category_scores_gemma":[0.00006068469,0.0001139194,0.0003337464,0.0002758908,0.0000620498,0.000005472101,0.0000329382,0.0003332563,6.538451e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005464043,"about_ca_system_score_gemma":0.0006955214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008482447,"about_ca_topic_score_gemma":0.000330095,"domain_scores_codex":[0.998431,0.0001588999,0.0004219791,0.0002070207,0.0001859991,0.0005950931],"domain_scores_gemma":[0.9992926,0.00001458679,0.0002078265,0.0002003043,0.0002278128,0.00005683717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001189296,0.000172154,0.02388356,0.00001259338,0.0006035934,0.000004573943,0.00003483813,0.0006124043,0.9716312,0.002119784,0.00002069482,0.0007856475],"study_design_scores_gemma":[0.0009381139,0.0007161296,0.001774748,0.000009202265,0.0005947049,0.00006643402,0.0002920069,0.000177172,0.9920972,0.002656984,0.000488253,0.0001890803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838852,0.004637209,0.01086474,0.00006005121,0.00009556949,0.00004412169,0.00001140062,0.00000355959,0.0003981967],"genre_scores_gemma":[0.9969306,0.001901086,0.0003678532,0.00004717052,0.0002045951,0.000001407985,0.0001111304,0.00001237023,0.0004237777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02210881,"threshold_uncertainty_score":0.4645498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009223299211472396,"score_gpt":0.2201793640142284,"score_spread":0.210956064802756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}