{"id":"W3204336527","doi":"10.1016/j.annonc.2021.08.1268","title":"858O Results of KEYNOTE-122: A phase III study of pembrolizumab (pembro) monotherapy vs chemotherapy (chemo) for platinum-pretreated, recurrent or metastatic (R/M) nasopharyngeal carcinoma (NPC)","year":2021,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of British Columbia","funders":"","keywords":"Medicine; Pembrolizumab; Chemotherapy; Nasopharyngeal carcinoma; Oncology; Internal medicine; Phases of clinical research; Radiation therapy; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002529111,0.001505098,0.002386945,0.0003706648,0.000518123,0.001358439,0.001143589,0.001689171,0.007683829],"category_scores_gemma":[0.001411788,0.0006122365,0.002027449,0.0004575034,0.0008170113,0.001021274,0.0003549835,0.003713464,0.001767126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008592366,"about_ca_system_score_gemma":0.001543619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001905366,"about_ca_topic_score_gemma":0.005054274,"domain_scores_codex":[0.9992591,0.0004339234,0.00004353938,0.00009250629,0.00005838194,0.0001125839],"domain_scores_gemma":[0.9989622,0.0002285727,0.0001495258,0.00008056833,0.00007321412,0.0005058726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9095269,0.03329878,0.002325093,0.0008069411,0.002260296,0.00008037483,0.000110601,0.0008219276,0.01589487,0.0001891557,0.004034812,0.03065011],"study_design_scores_gemma":[0.7375157,0.2474409,0.007663839,0.00004617068,0.001579605,0.00009413448,0.00005314021,0.0003921675,0.002335907,0.0001074877,0.002740996,0.00002990286],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796489,0.00398488,0.0004771527,0.0008396378,0.0004521684,0.002659809,0.006226168,0.0001459221,0.0055653],"genre_scores_gemma":[0.9716051,0.003881408,0.002151434,0.001725474,0.0005203228,0.002266616,0.01012628,0.00008537265,0.007637983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007683829,"threshold_uncertainty_score":0.02570504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1494558522740869,"score_gpt":0.4449146580096223,"score_spread":0.2954588057355354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}