{"id":"W3204339600","doi":"10.1016/j.biomaterials.2021.121178","title":"‘Green’ nanotherapeutics from tea leaves for orally targeted prevention and alleviation of colon diseases","year":2021,"lang":"en","type":"article","venue":"Biomaterials","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":293,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"Fundamental Research Funds for the Central Universities; Venture and Innovation Support Program for Chongqing Overseas Returnees; Natural Science Foundation of Chongqing; Chinese Academy of Sciences; Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission; National University's Basic Research Foundation of China; National Natural Science Foundation of China","keywords":"Endocytosis; Internalization; Reactive oxygen species; Inflammatory bowel disease; Colitis; Ulcerative colitis; Inflammation; Proinflammatory cytokine; Cancer research; Exosome; Microvesicles; Pharmacology; Receptor; Cell biology; Medicine; Immunology; Biology; Disease; microRNA; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006570586,0.000090063,0.0001240248,0.00001533018,0.00003532917,0.00002246617,0.00004899631,0.00009274186,0.00004385986],"category_scores_gemma":[0.00005151114,0.00009041735,0.00005657965,0.00001947873,0.0000380709,0.000004943061,0.00003937409,0.000002367708,0.000001410136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005431906,"about_ca_system_score_gemma":0.00008548092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001027851,"about_ca_topic_score_gemma":0.00003035519,"domain_scores_codex":[0.9993601,0.0000869303,0.0002047281,0.0001956601,0.00005951938,0.00009309326],"domain_scores_gemma":[0.9995741,0.00001015083,0.0001253422,0.0001616597,0.00008995141,0.00003884498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004052967,0.00006267861,0.00422898,0.00008960783,0.00008774616,0.000003327975,0.00002114451,9.073491e-7,0.9941539,0.00008901785,0.0001518943,0.000705497],"study_design_scores_gemma":[0.0006909513,0.00009094257,0.1072009,0.00001980802,0.00007032594,6.975989e-7,0.00001746987,0.00001224364,0.8886652,0.0005969857,0.002533822,0.0001006389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974232,0.0007705626,0.0004973578,0.00004731998,0.0001697306,0.0002593982,0.0008126065,0.00001091035,0.000008950808],"genre_scores_gemma":[0.9963818,0.00009924206,0.001549267,0.0000761982,0.0001654575,0.00004118107,0.001391267,0.00001696776,0.000278578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1054887,"threshold_uncertainty_score":0.3687112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124309668891761,"score_gpt":0.2636915134481774,"score_spread":0.2512605465590013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}