{"id":"W3204415261","doi":"10.1371/journal.pcbi.1009435","title":"Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits","year":2021,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Mila - Quebec Artificial Intelligence Institute","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Wellcome; Directorate for Biological Sciences; International Brain Research Organization; Wellcome Trust; Simons Foundation","keywords":"Neuroscience; Acetylcholine; Excitatory postsynaptic potential; Dentate gyrus; Hippocampal formation; Inhibitory postsynaptic potential; Postsynaptic potential; Hippocampus; Bursting; Mossy fiber (hippocampus); Biology; Chemistry; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001027156,0.0001019209,0.000177496,0.0002262873,0.0001193689,0.00001563994,0.0001281701,0.00005437512,0.00006089259],"category_scores_gemma":[0.0004804959,0.0000994933,0.0000298115,0.0005409166,0.0002200628,0.0001570124,0.00008400259,0.0002588063,0.00002856339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002218723,"about_ca_system_score_gemma":0.0001076827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002660423,"about_ca_topic_score_gemma":0.000004758591,"domain_scores_codex":[0.9985101,0.0003805238,0.0002671258,0.0003942909,0.000197814,0.0002502124],"domain_scores_gemma":[0.9986278,0.001036273,0.00008285727,0.00009279686,0.0000915832,0.00006862876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005574098,0.000288542,0.001088255,0.00001608173,0.000002167522,0.00004628945,0.00005011074,0.005031556,0.9897273,0.002746527,0.00005931476,0.0008881381],"study_design_scores_gemma":[0.0008044897,0.0002992286,0.004366412,0.00001166157,0.000004635509,0.0001905707,0.000009584818,0.02536177,0.9655451,0.00311714,0.0001970621,0.00009231504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975716,0.00002026223,0.0003152353,0.001339644,0.0001396173,0.0001428826,0.0000512696,0.00002069273,0.0003988029],"genre_scores_gemma":[0.9978977,0.00008092902,0.00007049927,0.001806623,0.00003494104,0.0000157866,0.00001740895,0.000007425995,0.00006871096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02418214,"threshold_uncertainty_score":0.4057219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1201955841741952,"score_gpt":0.3698637012864955,"score_spread":0.2496681171123003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}