{"id":"W3204439058","doi":"10.2139/ssrn.3931637","title":"Global Prediction of Candidate R-Loop Binding and R-Loop Regulatory Proteins","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"","keywords":"Loop (graph theory); Computational biology; Biology; Computer science; Mathematics; Combinatorics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003965588,0.001289684,0.001363723,0.001124933,0.00051661,0.0008393348,0.0004679187,0.0007959108,0.003817586],"category_scores_gemma":[0.0005252435,0.0003591315,0.00117284,0.0008393971,0.0002470585,0.0002609653,0.0002770358,0.0006278328,0.002886367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005199299,"about_ca_system_score_gemma":0.0005113371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007496729,"about_ca_topic_score_gemma":0.001670435,"domain_scores_codex":[0.9998066,0.0000270901,0.00001058524,0.00008166519,0.00004618226,0.00002800417],"domain_scores_gemma":[0.9995798,0.0001626703,0.00008233021,0.00003098275,0.00005100477,0.00009311404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002813515,0.0002883898,0.0143558,0.0006728754,0.0002533267,0.001219823,0.00006252541,0.0230224,0.9230953,0.001412344,0.002161,0.0306427],"study_design_scores_gemma":[0.0005610441,0.001482447,0.1254829,0.0001135048,0.001244265,0.001693422,0.0001965596,0.3995263,0.4506368,0.002687191,0.0162384,0.0001371869],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9418007,0.001642829,0.04271476,0.0001241646,0.00004658956,0.0001311404,0.007457741,0.002489305,0.003592828],"genre_scores_gemma":[0.9177059,0.0004712147,0.05414413,0.00008826541,0.00003736862,0.0001033942,0.02474154,0.0002604381,0.002447716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003817586,"threshold_uncertainty_score":0.01277113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005937672921004012,"score_gpt":0.2187422458087717,"score_spread":0.2128045728877677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}