{"id":"W3204463954","doi":"10.3390/biom11101479","title":"Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal General Hospital","funders":"National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Alcohol Abuse and Alcoholism; National Cancer Institute; National Institutes of Health; Thoracic Surgery Foundation; Columbia University; University of Pennsylvania; Massachusetts General Hospital; W. W. Smith Charitable Trust","keywords":"Autophagy; Organoid; Apoptosis; Programmed cell death; Oxidative stress; Cancer research; Cancer stem cell; Stem cell; CD44; Cell culture; Mitochondrion; Cancer cell; Cell; Chemistry; Cell biology; Cancer; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001592755,0.0003294399,0.0005528519,0.0001499525,0.0001564472,0.00004408788,0.000133524,0.0002037594,0.0005737814],"category_scores_gemma":[0.00001951706,0.0002940877,0.0001841182,0.000325022,0.0001898627,0.00008452254,0.0001043091,0.000252695,0.0002198036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001413072,"about_ca_system_score_gemma":0.0004901061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009279063,"about_ca_topic_score_gemma":0.0001998774,"domain_scores_codex":[0.9978288,0.0002956219,0.0003139162,0.0005906383,0.0004416132,0.0005294008],"domain_scores_gemma":[0.9985086,0.0001647002,0.0001802918,0.0004626402,0.0002912436,0.0003925602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001853155,0.000504095,0.01613,0.0009341224,0.0001104713,0.00107139,0.001462654,0.000004308962,0.9694566,0.0004155303,0.002078771,0.007646793],"study_design_scores_gemma":[0.002064526,0.00008285504,0.09014448,0.00005336616,0.0002290227,0.00003370951,0.0005189767,0.0001361495,0.9029641,0.00001077167,0.003490454,0.000271585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742992,0.02059371,0.0006710812,0.001275481,0.0008505906,0.0006305968,0.0001784526,0.0001303954,0.001370481],"genre_scores_gemma":[0.9941373,0.0004497842,0.0003888484,0.001638845,0.0002135134,0.0001015931,0.00007381827,0.00005471126,0.002941558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07401447,"threshold_uncertainty_score":0.9999511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07035369009557409,"score_gpt":0.3363028225525945,"score_spread":0.2659491324570204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}