{"id":"W3204463954","doi":"10.3390/biom11101479","title":"Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal General Hospital","funders":"National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Alcohol Abuse and Alcoholism; National Cancer Institute; National Institutes of Health; Thoracic Surgery Foundation; Columbia University; University of Pennsylvania; Massachusetts General Hospital; W. W. Smith Charitable Trust","keywords":"Autophagy; Organoid; Apoptosis; Programmed cell death; Oxidative stress; Cancer research; Cancer stem cell; Stem cell; CD44; Cell culture; Mitochondrion; Cancer cell; Cell; Chemistry; Cell biology; Cancer; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007981133,0.0001607853,0.0002078552,0.0002163451,0.0001704981,0.0003200516,0.00006695795,0.0001481502,0.001294838],"category_scores_gemma":[0.00006307984,0.00007448296,0.0002857244,0.0001714317,0.0001333895,0.0001866759,0.0002077898,0.000239476,0.0002864595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002276707,"about_ca_system_score_gemma":0.000219491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000671109,"about_ca_topic_score_gemma":0.001817392,"domain_scores_codex":[0.9999386,0.00000819176,0.00000626092,0.00001378453,0.00001712903,0.00001594511],"domain_scores_gemma":[0.9999447,0.000007098716,0.00001192231,0.000008806819,0.00001353642,0.00001387181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002069262,0.00004693261,0.003247636,0.00006395325,0.0000139786,0.0001048441,0.00004912106,0.0001039672,0.9920818,0.0001388455,0.0001098399,0.003832066],"study_design_scores_gemma":[0.00001542569,0.0003890167,0.04452361,0.00001662446,0.00005227142,0.0004492828,0.0001731491,0.001040798,0.9469467,0.0001305638,0.006253995,0.000008517099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943979,0.001588767,0.002063501,0.00007243137,0.00001681744,0.00002332371,0.0003945431,0.00004428473,0.001398317],"genre_scores_gemma":[0.9957515,0.0008066255,0.001562364,0.00005060033,0.000004637685,0.00001911705,0.0004494394,0.00001023702,0.001345444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294838,"threshold_uncertainty_score":0.004331708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07035369009557409,"score_gpt":0.3363028225525945,"score_spread":0.2659491324570204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}