{"id":"W3204465208","doi":"10.3390/cancers13194910","title":"Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Advancing Translational Sciences; Roche Diagnostics","keywords":"Triple-negative breast cancer; Concordance; Medicine; Immunohistochemistry; Atezolizumab; Pathology; Cancer; Breast cancer; Oncology; Internal medicine; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004981784,0.0002062644,0.0006793338,0.0001006667,0.00003565143,0.000006939809,0.0002155561,0.00006044185,0.0001911683],"category_scores_gemma":[0.0001657944,0.0001590729,0.0002131521,0.0004519338,0.0005262487,0.00005739582,0.0001294988,0.0001416584,2.10316e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002120712,"about_ca_system_score_gemma":0.001617536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00635379,"about_ca_topic_score_gemma":0.001188767,"domain_scores_codex":[0.9978331,0.0001210109,0.001099156,0.0003564398,0.0004087501,0.0001815124],"domain_scores_gemma":[0.997945,0.0001618078,0.001158417,0.0004216002,0.0002773822,0.00003580467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01409652,0.0008534461,0.116279,0.0004727883,0.002469992,0.0001775616,0.006161671,0.00009821349,0.8154562,0.00001918529,0.00017569,0.04373973],"study_design_scores_gemma":[0.00882745,0.0008253083,0.1168568,0.003771272,0.0002859675,0.0002465253,0.01432494,0.0001195977,0.8543164,0.00001449766,0.0002215959,0.0001896982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930694,0.00489334,0.00001155031,0.0001751096,0.0005564507,0.0006604631,0.0001840692,0.000004507425,0.0004450858],"genre_scores_gemma":[0.9993861,0.0001355539,0.0001419334,0.00006075947,0.00002849112,0.0001166291,0.00002628915,0.00001592838,0.0000882825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04355003,"threshold_uncertainty_score":0.9605073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745702372948846,"score_gpt":0.3199843105720592,"score_spread":0.2925272868425707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}