{"id":"W3204465208","doi":"10.3390/cancers13194910","title":"Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Advancing Translational Sciences; Roche Diagnostics","keywords":"Triple-negative breast cancer; Concordance; Medicine; Immunohistochemistry; Atezolizumab; Pathology; Cancer; Breast cancer; Oncology; Internal medicine; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03076715,0.0008151481,0.0006435129,0.001003498,0.0006335084,0.0009323796,0.0009390899,0.001117238,0.001346854],"category_scores_gemma":[0.02528205,0.0007626503,0.0008349363,0.0004489457,0.001414152,0.0008295915,0.001731601,0.0009144573,0.0005511569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007149667,"about_ca_system_score_gemma":0.0006000958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001130167,"about_ca_topic_score_gemma":0.001287473,"domain_scores_codex":[0.9792179,0.008979768,0.001098966,0.004485734,0.00554789,0.0006698152],"domain_scores_gemma":[0.9546921,0.02397902,0.004044555,0.004816368,0.01125025,0.001217767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01686241,0.003196797,0.4946422,0.0009494528,0.001526809,0.0004616408,0.005062131,0.003837251,0.406743,0.0004207706,0.001354218,0.06494328],"study_design_scores_gemma":[0.0009772002,0.0155475,0.7335002,0.00007906785,0.001481992,0.002604614,0.001230547,0.0362091,0.2031105,0.0006121284,0.004407555,0.0002395566],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788711,0.0009576702,0.01804668,0.00005300168,0.0001150444,0.0004790324,0.0002857982,0.0001088983,0.001082719],"genre_scores_gemma":[0.9876705,0.0001240244,0.01078191,0.00005545874,0.00006677968,0.0004186219,0.0004378963,0.00003433814,0.0004104143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03076715,"threshold_uncertainty_score":0.1627142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745702372948846,"score_gpt":0.3199843105720592,"score_spread":0.2925272868425707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}