{"id":"W3204530276","doi":"10.1016/j.jid.2021.07.187","title":"Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages","year":2021,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Hidradenitis Suppurativa and Treatments","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Institutes of Health; Novartis; Pfizer; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Eli Lilly and Company","keywords":"Autoantibody; Proinflammatory cytokine; Immunology; Antigen; Immune system; Medicine; Hidradenitis suppurativa; Antibody; Autoimmune disease; Inflammation; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005194917,0.0003285382,0.0003316215,0.0006462064,0.0001976496,0.0003698244,0.0001142069,0.0004694172,0.00151911],"category_scores_gemma":[0.00075913,0.0002304847,0.0002940824,0.0002698069,0.0002193766,0.0002891011,0.0002820655,0.0005859363,0.0003179605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001311911,"about_ca_system_score_gemma":0.0001081924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002127437,"about_ca_topic_score_gemma":0.0002625027,"domain_scores_codex":[0.9994394,0.0001921999,0.00006811041,0.00006403992,0.0001158087,0.0001203393],"domain_scores_gemma":[0.9992331,0.0001360101,0.000334328,0.00004729161,0.000117809,0.000131385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002329621,0.0006181478,0.3750426,0.0003976031,0.0002145773,0.002647882,0.0003915268,0.0001591957,0.6007867,0.0001575849,0.0006849411,0.01656953],"study_design_scores_gemma":[0.00008567639,0.001313347,0.9557366,0.00006291767,0.0001414306,0.005949994,0.000460715,0.0006267568,0.03311385,0.0001987965,0.002292615,0.00001722623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941264,0.003782759,0.0005003336,0.0000965713,0.00005564239,0.00002754556,0.0001060119,0.00002006095,0.001284611],"genre_scores_gemma":[0.9982036,0.0006136469,0.0003769065,0.00008748233,0.00008966083,0.00002162096,0.0001079614,0.00000343871,0.0004956093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00151911,"threshold_uncertainty_score":0.005081952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01296197309098638,"score_gpt":0.255421043574145,"score_spread":0.2424590704831586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}