{"id":"W3204588330","doi":"10.1016/j.annonc.2021.08.1489","title":"1380P Phase (Ph) II study of zanidatamab + chemotherapy (chemo) in first-line (1L) HER2 expressing gastroesophageal adenocarcinoma (GEA)","year":2021,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Zymeworks (Canada); Princess Margaret Cancer Centre","funders":"Astellas Pharma; Natera; Pharmacyclics; MacroGenics; BeiGene; Daiichi Sankyo Europe; Eli Lilly and Company; Bristol-Myers Squibb; Incyte; Amgen","keywords":"Medicine; Internal medicine; Hypokalemia; Oxaliplatin; Gastroenterology; Vomiting; Nausea; Capecitabine; Adverse effect; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009278578,0.001273964,0.002164359,0.0004740178,0.0003528099,0.001070821,0.0008126062,0.0009691825,0.007668864],"category_scores_gemma":[0.0006342315,0.0005518137,0.001408656,0.0004307034,0.000747225,0.0006762974,0.0004016376,0.003302997,0.001628257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001217784,"about_ca_system_score_gemma":0.002040436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002471837,"about_ca_topic_score_gemma":0.006101386,"domain_scores_codex":[0.9997097,0.0001059689,0.00001180606,0.00004944675,0.00002742152,0.00009573178],"domain_scores_gemma":[0.9995484,0.00004617016,0.00006009664,0.00004491786,0.00003189524,0.0002685061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7865449,0.0470433,0.005771442,0.00086269,0.001189982,0.0001830322,0.0002061466,0.002335344,0.03910457,0.00053194,0.007148477,0.1090782],"study_design_scores_gemma":[0.5959067,0.3796835,0.01223464,0.00004385743,0.0006327204,0.0002528075,0.00007539507,0.0009464531,0.004722633,0.0003580961,0.005114399,0.00002873323],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881457,0.00134897,0.000471725,0.0006390168,0.0002115307,0.00227154,0.003623173,0.0001119978,0.003176266],"genre_scores_gemma":[0.9719039,0.002571253,0.002109113,0.001340779,0.000194905,0.002807204,0.008488619,0.00008244814,0.01050188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007668864,"threshold_uncertainty_score":0.02565485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.161775781532972,"score_gpt":0.4767629339354125,"score_spread":0.3149871524024406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}