{"id":"W3204702236","doi":"10.1101/2021.09.29.462278","title":"Two helices control the dynamic crosstalk between the catalytic domains of LRRK2","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; National Cancer Institute; National Institutes of Health; Ministero dello Sviluppo Economico; Deutsche Forschungsgemeinschaft; Merck KGaA; Merck Sharp and Dohme; Ontario Ministry of Economic Development and Innovation; Genome Canada","keywords":"LRRK2; Allosteric regulation; Helix (gastropod); Protein kinase domain; Kinase; Crosstalk; Chemistry; Leucine-rich repeat; Biophysics; Transferase; Hydrogen–deuterium exchange; Crystallography; Biochemistry; Biology; Physics; Enzyme; Mutation; Hydrogen","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001225642,0.0001787563,0.0001835086,0.00007073472,0.0002145485,0.0002730281,0.0001803187,0.0001822163,0.0009582302],"category_scores_gemma":[0.0001237902,0.0001272079,0.0001102393,0.00006758876,0.0002559728,0.0002118322,0.0001788877,0.0002298913,0.00018689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003105469,"about_ca_system_score_gemma":0.0001551067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005083668,"about_ca_topic_score_gemma":0.000620692,"domain_scores_codex":[0.9999535,0.000007405055,0.000001928216,0.00001398687,0.00001194288,0.00001131853],"domain_scores_gemma":[0.9999603,0.000009875333,0.00000888844,0.000004171291,0.000004019913,0.00001269429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003151621,0.00005094167,0.002872724,0.00004480243,0.00002126274,0.0001460555,0.00006127738,0.01787813,0.9732051,0.002193378,0.0002433981,0.002967686],"study_design_scores_gemma":[0.0002060221,0.000229033,0.02069277,0.00001878261,0.00004532958,0.0002982708,0.0002021362,0.3816098,0.5896012,0.002910519,0.004136607,0.00004954656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948276,0.0001115163,0.003892712,0.00004321813,0.0000083647,0.000004785036,0.00005201446,0.00006452311,0.0009952378],"genre_scores_gemma":[0.9990854,0.000029628,0.0006899377,0.00001223359,0.000001133096,0.000002651622,0.00004216923,0.000007859231,0.0001289089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009582302,"threshold_uncertainty_score":0.003205597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007341397599259598,"score_gpt":0.2202682927384613,"score_spread":0.2129268951392017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}