{"id":"W3204702248","doi":"10.1016/j.euroneuro.2021.08.073","title":"TU71. SIGNIFICANT INCIDENCE OF RARE CHROMOSOMAL AND GENOMIC SEQUENCE VARIANTS IN HIGHLY TREATMENT-RESISTANT SCHIZOPHRENIA AND SCHIZOAFFECTIVE DISORDER","year":2021,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Fraser Health; University of Calgary; University of British Columbia","funders":"","keywords":"Endoplasmic reticulum; STAT3; Signal transduction; Inflammation; Transcription factor; Biology; Unfolded protein response; Cancer research; Medicine; Internal medicine; Cell biology; Endocrinology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003124037,0.0008457184,0.0004864447,0.002010216,0.001230311,0.0005733042,0.0005780378,0.00135695,0.01339334],"category_scores_gemma":[0.001852593,0.0002048535,0.0006458022,0.001942491,0.0004602998,0.0002821842,0.0004038088,0.0007454413,0.001087681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002090864,"about_ca_system_score_gemma":0.000303396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003546564,"about_ca_topic_score_gemma":0.003549494,"domain_scores_codex":[0.9994112,0.0001515268,0.00008325749,0.000150863,0.00009896807,0.000104165],"domain_scores_gemma":[0.9983066,0.0005676284,0.0006772305,0.0001009972,0.0001022985,0.0002450566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01293193,0.0007785441,0.6856624,0.0004790051,0.00159238,0.04244091,0.001335832,0.0009375965,0.1878522,0.004136594,0.005750701,0.05610179],"study_design_scores_gemma":[0.0002283194,0.0008439874,0.9490316,0.00009668877,0.0005663811,0.03633461,0.0006410395,0.001027207,0.005546045,0.001399685,0.004199503,0.00008494505],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944476,0.001058888,0.0005747292,0.0002360048,0.00008062717,0.0000168578,0.001791519,0.00005214407,0.001741667],"genre_scores_gemma":[0.998187,0.0001106264,0.0001927155,0.00005730279,0.00003692718,0.000007352685,0.0006259416,0.0000186064,0.0007635833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01339334,"threshold_uncertainty_score":0.04480517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008973568500445258,"score_gpt":0.2589496887769456,"score_spread":0.2499761202765003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}