{"id":"W3204750817","doi":"10.1016/b978-0-12-822003-0.00005-x","title":"Regulation of autophagy—transcriptional, posttranscriptional, translational, and posttranslational mechanisms","year":2021,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Autophagy; Cell biology; TFEB; BAG3; PI3K/AKT/mTOR pathway; ATG16L1; Lysosome; AMPK; Biology; Post-translational regulation; ULK1; Ubiquitin; Translational regulation; Epigenetics; Phosphorylation; Autophagy-related protein 13; Chemistry; Signal transduction; Protein kinase A; Translation (biology); Biochemistry; Messenger RNA; Gene; Protein phosphorylation; Enzyme; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001817058,0.0003700966,0.0005130454,0.0005980118,0.0002883592,0.001786605,0.0003983239,0.0005083348,0.006340354],"category_scores_gemma":[0.00008178929,0.0001664824,0.0002532411,0.0007857569,0.0006257521,0.001285,0.0004986621,0.001255165,0.003816366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006935311,"about_ca_system_score_gemma":0.0004195861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004020431,"about_ca_topic_score_gemma":0.0008795987,"domain_scores_codex":[0.9999144,0.000008790786,0.000005504156,0.00001910741,0.00004289252,0.000009316062],"domain_scores_gemma":[0.9999548,0.00001557697,0.000006219464,0.000003709118,0.00001248421,0.000007148735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000195966,0.0001038654,0.0003127768,0.001503427,0.00002401744,0.0003003,0.0003380446,0.0008048104,0.1121305,0.1844995,0.08838016,0.6114066],"study_design_scores_gemma":[0.000009878859,0.00005019818,0.001298488,0.0003949458,0.00001203058,0.0006259839,0.0001624703,0.0004894995,0.01524853,0.03841778,0.9432711,0.00001897259],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009562858,0.6906682,0.011558,0.005288127,0.002306656,0.00003400208,0.0003875745,0.0003259674,0.2798687],"genre_scores_gemma":[0.0543036,0.5196214,0.01282894,0.002568098,0.001529426,0.00009119151,0.0006048726,0.0001331156,0.4083193],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006340354,"threshold_uncertainty_score":0.02121061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0216728335020719,"score_gpt":0.2567613840023701,"score_spread":0.2350885505002982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}