{"id":"W3204760583","doi":"10.1200/jco.21.00920","title":"Dose-Adjusted Etoposide, Doxorubicin, and Cyclophosphamide With Vincristine and Prednisone Plus Rituximab Therapy in Children and Adolescents With Primary Mediastinal B-Cell Lymphoma: A Multicenter Phase II Trial","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; National Institute for Health and Care Research; Cancer Research UK","keywords":"Prednisone; Vincristine; Rituximab; Cyclophosphamide; Multicenter study; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001542588,0.0007253088,0.001136483,0.0002322675,0.0002377665,0.0006685118,0.0005716818,0.0005628293,0.001085228],"category_scores_gemma":[0.0007930166,0.0002436258,0.0009242847,0.000335896,0.0005355089,0.0004025171,0.0002986097,0.001722421,0.0002227784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006157465,"about_ca_system_score_gemma":0.001162767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004990626,"about_ca_topic_score_gemma":0.00164083,"domain_scores_codex":[0.9993951,0.0003737083,0.00005031949,0.00007477887,0.00004766603,0.00005845887],"domain_scores_gemma":[0.999285,0.0001085068,0.0002184727,0.00004389515,0.00004453829,0.0002996027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6632472,0.0504965,0.06241356,0.002389883,0.004018568,0.0008762851,0.00064396,0.004234673,0.02508137,0.0006883067,0.004146265,0.1817634],"study_design_scores_gemma":[0.6114932,0.3246654,0.05005446,0.0002662823,0.001500331,0.001047485,0.0001748836,0.001856282,0.002837051,0.0002085998,0.005866639,0.0000294305],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939969,0.003860911,0.0002577889,0.0001815208,0.00004497589,0.0007991456,0.0002647439,0.00001928107,0.0005746486],"genre_scores_gemma":[0.9925348,0.002776866,0.001588511,0.0005197534,0.0001121495,0.001257134,0.0007286741,0.00001012836,0.0004719766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001542588,"threshold_uncertainty_score":0.008158028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03384742794814694,"score_gpt":0.358939407888644,"score_spread":0.3250919799404971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}